PI3K-Akt signaling pathway

Knockdown of TUG1 decreased the ratio of apoptotic cells and promoted cells survival in vitro, which may be regulated by the elevated miRNA-9 expression and decreased Bcl2l11 protein.

LncRNA TUG1 sponges microRNA-9 to promote neurons apoptosis by up-regulated Bcl2l11 under ischemia

PI3K-Akt signaling pathway

Furthermore, TUG1 could directly interact with miR-9 and down-regulating miR-9 could efficiently reverse the function of TUG1 on the Bcl2l11 expression.

LncRNA TUG1 sponges microRNA-9 to promote neurons apoptosis by up-regulated Bcl2l11 under ischemia

One carbon pool by folate；Metabolic pathways

TUG1 knockdown reduced proliferation, suppressed cell cycle progression, and promoted apoptosis of MCF-7 cells. The dual luciferase reporter assay showed that TUG1 could negatively regulate the expression of miR-9. MiR-9 inhibition abrogated the effect of TUG1 knockdown on the proliferation, cell cycle progression, and apoptosis of MCF-7 cells. TUG1 positively regulated the expression of MTHFD2 in breast cancer cells.

LncRNA Taurine-Upregulated Gene 1 Promotes Cell Proliferation by Inhibiting MicroRNA-9 in MCF-7 Cells

Cell cycle；MAPK signaling pathway；Small cell lung cancer；ErbB signaling pathway；PI3K-Akt signaling pathway；Wnt signaling pathway；Chronic myeloid leukemia；TGF-beta signaling pathway；Thyroid cancer；Colorectal cancer； Bladder cancer；Transcriptional misregulation in cancer；Proteoglycans in cancer；Hippo signaling pathway；Jak-STAT signaling pathway；Hepatitis B；Acute myeloid leukemia；Endometrial cancer；HTLV-I infection；Epstein-Barr virus infection；Pathways in cancer

Linc00176 is expressed at a high level only in HCC, and is activated by Myc, Max and AP-4 transcription regulators. Myc also upregulates miR-9 and miR-185. In Linc00176-depleted HCC, these miRNAs were released from Linc00176 and downregulated their target mRNAs. Thus, depletion of Linc00176 disrupted the cell cycle and induced necroptosis in HCC via released tumor suppressor miRNAs

Myc target gene, long intergenic noncoding RNA, Linc00176 in hepatocellular carcinoma regulates cell cycle and cell survival by titrating tumor suppressor microRNAs.

ErbB signaling pathway；HIF-1 signaling pathway；Cell cycle；p53 signaling pathway；PI3K-Akt signaling pathway；Hepatitis C；Hepatitis B；Bladder cancer；Chronic myeloid leukemia；Melanoma；HTLV-I infection；Glioma；Epstein-Barr virus infection；Pathways in cancer；Transcriptional misregulation in cancer；Prostate cancer；Viral carcinogenesis；Proteoglycans in cancer

circMTO1 suppresses HCC progression by acting as the sponge of oncogenic miR-9 to promote p21 expression, suggesting that circMTO1 is a potential target in HCC treatment.

circMTO1 suppresses HCC progression by acting as the sponge of oncogenic miR-9 to promote p21 expression, suggesting that circMTO1 is a potential target in HCC treatment.