Dopaminergic synapse；MAPK signaling pathway；PI3K-Akt signaling pathway；Insulin secretion； Estrogen signaling pathway；Cocaine addiction；Epstein-Barr virus infection； Amphetamine addiction；Alcoholism； Hepatitis B；Influenza A； HTLV-I infection；Viral carcinogenesis

UCA1 directly interacted with miR-204 and decreased the binding of miR-204 to ATF2 3'UTR, which suppressed the degradation of ATF2 mRNA by miR-204.

Long non-coding RNA UCA1 promotes cell progression by acting as a competing endogenous RNA of ATF2 in prostate cancer

Dopaminergic synapse；MAPK signaling pathway；PI3K-Akt signaling pathway；Insulin secretion； Estrogen signaling pathway；Cocaine addiction；Epstein-Barr virus infection； Amphetamine addiction；Alcoholism； Hepatitis B；Influenza A； HTLV-I infection；Viral carcinogenesis

Silencing of hsa_circ_0001859 suppressed ATF2 expression and decreased inflammatory activity in SW982 cells. Hsa_circ_0001859 could compete with ATF2 for miR-204/211.

Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis

Dopaminergic synapse；MAPK signaling pathway；PI3K-Akt signaling pathway；Insulin secretion； Estrogen signaling pathway；Cocaine addiction；Epstein-Barr virus infection； Amphetamine addiction；Alcoholism； Hepatitis B；Influenza A； HTLV-I infection；Viral carcinogenesis

Silencing of hsa_circ_0001859 suppressed ATF2 expression and decreased inflammatory activity in SW982 cells. Hsa_circ_0001859 could compete with ATF2 for miR-204/211.

Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis

Dopaminergic synapse；PI3K-Akt signaling pathway；HTLV-I infection；Huntington's disease；Hepatitis B；Osteoclast differentiation；Antigen processing and presentation；Circadian rhythm；Alcoholism；Circadian entrainment；Cholinergic synapse；Prostate cancer；Viral carcinogenesis；Cocaine addiction；Tuberculosis；Insulin secretion；Estrogen signaling pathway；Melanogenesis；Amphetamine addiction；Vasopressin-regulated water reabsorption

Moreover, UCA1 activated transcription factor CREB which led to miR-196a-5p expression by binding with its promoter. miR-196a-5p induction is involved in UCA1 inhibition of apoptosis induced by cisplatin/gemcitabine via targeting p27Kip1

Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells

Dopaminergic synapse；PI3K-Akt signaling pathway；HTLV-I infection；Huntington's disease；Hepatitis B；Osteoclast differentiation；Antigen processing and presentation；Circadian rhythm；Alcoholism；Circadian entrainment；Cholinergic synapse；Prostate cancer；Viral carcinogenesis；Cocaine addiction；Tuberculosis；Insulin secretion；Estrogen signaling pathway；Melanogenesis；Amphetamine addiction；Vasopressin-regulated water reabsorption

Furthermore, we demonstrated HULC may act as an endogenous 'sponge', which down-regulates a series of microRNAs (miRNAs) activities, including miR-372. Inhibition of miR-372 leads to reducing translational repression of its target gene, PRKACB, which in turn induces phosphorylation of CREB.

CREB up-regulates long non-coding RNA, HULC expression through interaction with microRNA-372 in liver cancer

Osteoclast differentiation；PI3K-Akt signaling pathway；Antigen processing and presentation； Circadian rhythm；Circadian entrainment；HTLV-I infection；Cholinergic synapse；Dopaminergic synapse；Cocaine addiction；Amphetamine addiction；Tuberculosis；Insulin secretion；Prostate cancer；Huntington's disease；Viral carcinogenesis； Estrogen signaling pathway；Melanogenesis；Hepatitis B；Alcoholism； Vasopressin-regulated water reabsorption

The protein levels of CREB1 were significantly up-regulated in CRCs, negatively associated with survival time and positively correlated with the UCA1 expression. The present work provides the first evidence of a UCA1-miR-204-5p-CREB1/BCL2/RAB22A regulatory network in CRC and reveals that UCA1 and CREB1 are potential new oncogenes and prognostic factors for CRC.

LncRNA-UCA1 enhances cell proliferation and 5-fluorouracil resistance in colorectal cancer by inhibiting miR-204-5p