NOD-like receptor signaling pathway；Cytokine-cytokine receptor interaction；HIF-1 signaling pathway；PI3K-Akt signaling pathway；Toll-like receptor signaling pathway；Legionellosis；Hypertrophic cardiomyopathy (HCM)；African trypanosomiasis；Cytosolic DNA-sensing pathway；Jak-STAT signaling pathway；Hematopoietic cell lineage；Intestinal immune network for IgA production；Transcriptional misregulation in cancer；Influenza A； Herpes simplex infection；Pathways in cancer；Chagas disease (American trypanosomiasis)；Graft-versus-host disease；Malaria；Prion diseases；Pertussis；Rheumatoid arthritis；Measles；Salmonella infection；Amoebiasis；Hepatitis B；HTLV-I infection；Tuberculosis

H19 and HULC functioned as competing endogenous RNAs (ceRNAs) by sponging let-7a/let-7b and miR-372/miR-373, respectively, which activate pivotal inflammation cytokine IL-6 and chemokine receptor CXCR4.

LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner

NOD-like receptor signaling pathway；Cytokine-cytokine receptor interaction；HIF-1 signaling pathway；PI3K-Akt signaling pathway；Toll-like receptor signaling pathway；Legionellosis；Hypertrophic cardiomyopathy (HCM)；African trypanosomiasis；Cytosolic DNA-sensing pathway；Jak-STAT signaling pathway；Hematopoietic cell lineage；Intestinal immune network for IgA production；Transcriptional misregulation in cancer；Influenza A； Herpes simplex infection；Pathways in cancer；Chagas disease (American trypanosomiasis)；Graft-versus-host disease；Malaria；Prion diseases；Pertussis；Rheumatoid arthritis；Measles；Salmonella infection；Amoebiasis；Hepatitis B；HTLV-I infection；Tuberculosis

H19 and HULC functioned as competing endogenous RNAs (ceRNAs) by sponging let-7a/let-7b and miR-372/miR-373, respectively, which activate pivotal inflammation cytokine IL-6 and chemokine receptor CXCR4.

LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner

NOD-like receptor signaling pathway；Cytokine-cytokine receptor interaction；HIF-1 signaling pathway；PI3K-Akt signaling pathway；Toll-like receptor signaling pathway；Legionellosis；Hypertrophic cardiomyopathy (HCM)；African trypanosomiasis；Cytosolic DNA-sensing pathway；Jak-STAT signaling pathway；Hematopoietic cell lineage；Intestinal immune network for IgA production；Transcriptional misregulation in cancer；Influenza A； Herpes simplex infection；Pathways in cancer；Chagas disease (American trypanosomiasis)；Graft-versus-host disease；Malaria；Prion diseases；Pertussis；Rheumatoid arthritis；Measles；Salmonella infection；Amoebiasis；Hepatitis B；HTLV-I infection；Tuberculosis

H19 and HULC functioned as competing endogenous RNAs (ceRNAs) by sponging let-7a/let-7b and miR-372/miR-373, respectively, which activate pivotal inflammation cytokine IL-6 and chemokine receptor CXCR4.

LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner

NOD-like receptor signaling pathway；Cytokine-cytokine receptor interaction；HIF-1 signaling pathway；PI3K-Akt signaling pathway；Toll-like receptor signaling pathway；Legionellosis；Hypertrophic cardiomyopathy (HCM)；African trypanosomiasis；Cytosolic DNA-sensing pathway；Jak-STAT signaling pathway；Hematopoietic cell lineage；Intestinal immune network for IgA production；Transcriptional misregulation in cancer；Influenza A； Herpes simplex infection；Pathways in cancer；Chagas disease (American trypanosomiasis)；Graft-versus-host disease；Malaria；Prion diseases；Pertussis；Rheumatoid arthritis；Measles；Salmonella infection；Amoebiasis；Hepatitis B；HTLV-I infection；Tuberculosis

H19 and HULC functioned as competing endogenous RNAs (ceRNAs) by sponging let-7a/let-7b and miR-372/miR-373, respectively, which activate pivotal inflammation cytokine IL-6 and chemokine receptor CXCR4.

LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner

NOD-like receptor signaling pathway；Cytokine-cytokine receptor interaction；HIF-1 signaling pathway；PI3K-Akt signaling pathway；Toll-like receptor signaling pathway；Legionellosis；Hypertrophic cardiomyopathy (HCM)；African trypanosomiasis；Cytosolic DNA-sensing pathway；Jak-STAT signaling pathway；Hematopoietic cell lineage；Intestinal immune network for IgA production；Transcriptional misregulation in cancer；Influenza A； Herpes simplex infection；Pathways in cancer；Chagas disease (American trypanosomiasis)；Graft-versus-host disease；Malaria；Prion diseases；Pertussis；Rheumatoid arthritis；Measles；Salmonella infection；Amoebiasis；Hepatitis B；HTLV-I infection；Tuberculosis

H19 and HULC functioned as competing endogenous RNAs (ceRNAs) by sponging let-7a/let-7b and miR-372/miR-373, respectively, which activate pivotal inflammation cytokine IL-6 and chemokine receptor CXCR4.

LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner

NOD-like receptor signaling pathway；Cytokine-cytokine receptor interaction；HIF-1 signaling pathway；PI3K-Akt signaling pathway；Toll-like receptor signaling pathway；Legionellosis；Hypertrophic cardiomyopathy (HCM)；African trypanosomiasis；Cytosolic DNA-sensing pathway；Jak-STAT signaling pathway；Hematopoietic cell lineage；Intestinal immune network for IgA production；Transcriptional misregulation in cancer；Influenza A； Herpes simplex infection；Pathways in cancer；Chagas disease (American trypanosomiasis)；Graft-versus-host disease；Malaria；Prion diseases；Pertussis；Rheumatoid arthritis；Measles；Salmonella infection；Amoebiasis；Hepatitis B；HTLV-I infection；Tuberculosis

H19 and HULC functioned as competing endogenous RNAs (ceRNAs) by sponging let-7a/let-7b and miR-372/miR-373, respectively, which activate pivotal inflammation cytokine IL-6 and chemokine receptor CXCR4.

LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner

NOD-like receptor signaling pathway；Cytokine-cytokine receptor interaction；HIF-1 signaling pathway；PI3K-Akt signaling pathway；Toll-like receptor signaling pathway；Legionellosis；Hypertrophic cardiomyopathy (HCM)；African trypanosomiasis；Cytosolic DNA-sensing pathway；Jak-STAT signaling pathway；Hematopoietic cell lineage；Intestinal immune network for IgA production；Transcriptional misregulation in cancer；Influenza A； Herpes simplex infection；Pathways in cancer；Chagas disease (American trypanosomiasis)；Graft-versus-host disease；Malaria；Prion diseases；Pertussis；Rheumatoid arthritis；Measles；Salmonella infection；Amoebiasis；Hepatitis B；HTLV-I infection；Tuberculosis

H19 and HULC functioned as competing endogenous RNAs (ceRNAs) by sponging let-7a/let-7b and miR-372/miR-373, respectively, which activate pivotal inflammation cytokine IL-6 and chemokine receptor CXCR4.

LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner

NOD-like receptor signaling pathway；Cytokine-cytokine receptor interaction；HIF-1 signaling pathway；PI3K-Akt signaling pathway；Toll-like receptor signaling pathway；Legionellosis；Hypertrophic cardiomyopathy (HCM)；African trypanosomiasis；Cytosolic DNA-sensing pathway；Jak-STAT signaling pathway；Hematopoietic cell lineage；Intestinal immune network for IgA production；Transcriptional misregulation in cancer；Influenza A； Herpes simplex infection；Pathways in cancer；Chagas disease (American trypanosomiasis)；Graft-versus-host disease；Malaria；Prion diseases；Pertussis；Rheumatoid arthritis；Measles；Salmonella infection；Amoebiasis；Hepatitis B；HTLV-I infection；Tuberculosis

H19 and HULC functioned as competing endogenous RNAs (ceRNAs) by sponging let-7a/let-7b and miR-372/miR-373, respectively, which activate pivotal inflammation cytokine IL-6 and chemokine receptor CXCR4.

LncRNAs H19 and HULC, activated by oxidative stress, promote cell migration and invasion in cholangiocarcinoma through a ceRNA manner

NOD-like receptor signaling pathway；Cytokine-cytokine receptor interaction；HIF-1 signaling pathway；PI3K-Akt signaling pathway；Toll-like receptor signaling pathway；Legionellosis；Hypertrophic cardiomyopathy (HCM)；African trypanosomiasis；Cytosolic DNA-sensing pathway；Jak-STAT signaling pathway；Hematopoietic cell lineage；Intestinal immune network for IgA production；Transcriptional misregulation in cancer；Influenza A； Herpes simplex infection；Pathways in cancer；Chagas disease (American trypanosomiasis)；Graft-versus-host disease；Malaria；Prion diseases；Pertussis；Rheumatoid arthritis；Measles；Salmonella infection；Amoebiasis；Hepatitis B；HTLV-I infection；Tuberculosis

Furthermore, when overexpression of mmu-miR-485-5p, IL-6 mRNA was markedly decreased. The results demonstrated that CGRP-induced IL-6 mRNA expression was mediated by mmu_circRNA_007893, and mmu_circRNA_007893 functioned as an endogenous mmu-miR-485-5p sponge as part of induction of IL-6 mRNA expression.

Calcitonin gene?related peptide induces IL?6 expression in RAW264.7 macrophages mediated by mmu_circRNA_007893

Cytokine-cytokine receptor interaction；HIF-1 signaling pathway；PI3K-Akt signaling pathway；Jak-STAT signaling pathway；Hematopoietic cell lineage

Direct interaction of circ_0009910 and miR-449a was confirmed through dual-luciferase assays. Moreover, IL6R was predicted as a potential target of miR-449a. Overexpression of miR-449a decreased the mRNA and protein levels of IL6R.

Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma