| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| circ-ITCH | miR-17 | p21 | CDKN1A；CAP20；CDKN1；CIP1；MDA-6；P21；SDI1；WAF1；p21CIP1 | details
ErbB signaling pathway；HIF-1 signaling pathway；Cell cycle；p53 signaling pathway；PI3K-Akt signaling pathway；Hepatitis C；Hepatitis B；Bladder cancer；Chronic myeloid leukemia；Melanoma；HTLV-I infection；Glioma；Epstein-Barr virus infection；Pathways in cancer；Transcriptional misregulation in cancer；Prostate cancer；Viral carcinogenesis；Proteoglycans in cancer
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details
Mechanistically, we demonstrated that circ-ITCH up-regulates the expression of miR-17 and miR-224 target gene p21 and PTEN through 'sponging' miR-17 and miR-224, which suppressed the aggressive biological behaviors of BCa.
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Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression.
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Bladder cancer | Mol Cancer. | 29386015 |