LncCeRBase

Welcome to the LncCeRBase DataBase!
LncRNA MiRNA Gene Gene name Pathway Name Description Title Disease/Tissue Journal PubMed ID
GAS5 miR-103 AKT AKT1;AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA details
Cholinergic synapse;HIF-1 signaling pathway;Chemokine signaling pathway;MAPK signaling pathway;Small cell lung cancer;Toll-like receptor signaling pathway;Fc epsilon RI signaling pathway;T cell receptor signaling pathway;ErbB signaling pathway;Carbohydrate digestion and absorption;Chagas disease (American trypanosomiasis);mTOR signaling pathway;PI3K-Akt signaling pathway;Hepatitis B;HTLV-I infection;Pathways in cancer;Toxoplasmosis;Colorectal cancer;Endometrial cancer;Jak-STAT signaling pathway;Neurotrophin signaling pathway;Influenza A;Proteoglycans in cancer; Measles;Dopaminergic synapse;Tuberculosis;Prostate cancer;Non-small cell lung cancer;Apoptosis;Progesterone-mediated oocyte maturation;Melanoma;Chronic myeloid leukemia; B cell receptor signaling pathway; Insulin signaling pathway;Renal cell carcinoma;Estrogen signaling pathway;VEGF signaling pathway;Osteoclast differentiation;Glioma;Epstein-Barr virus infection; Focal adhesion;Tight junction;Hepatitis C;Fc gamma R-mediated phagocytosis;Pancreatic cancer;Acute myeloid leukemia;Adipocytokine signaling pathway
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The exposure levels of the proteins related to the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) axis, including AKT, mTOR, and S6K1, were measured by western blot PC3 cells infected with lncRNA GAS5 mimic; lncRNA GAS5 siRNA; or a combination of lncRNA and miR-103.
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LncRNA GAS5 inhibits proliferation and progression of prostate cancer by targeting miR-103 through AKT/mTOR signaling pathway
Prostate Cancer Tumour Biol 27743383
LINC00052 miR-193a-3p AKT AKT2;:HIHGHH;PKBB;PKBBETA;PRKBB;RAC-BETA details
Cholinergic synapse;HIF-1 signaling pathway;Chemokine signaling pathway;MAPK signaling pathway;Small cell lung cancer;Toll-like receptor signaling pathway;Fc epsilon RI signaling pathway;T cell receptor signaling pathway;ErbB signaling pathway;Carbohydrate digestion and absorption;Chagas disease (American trypanosomiasis);mTOR signaling pathway;PI3K-Akt signaling pathway;Hepatitis B;HTLV-I infection;Pathways in cancer;Toxoplasmosis;Colorectal cancer;Endometrial cancer;Jak-STAT signaling pathway;Neurotrophin signaling pathway;Influenza A;Proteoglycans in cancer; Measles;Dopaminergic synapse;Tuberculosis;Prostate cancer;Non-small cell lung cancer;Apoptosis;Progesterone-mediated oocyte maturation;Melanoma;Chronic myeloid leukemia; B cell receptor signaling pathway; Insulin signaling pathway;Renal cell carcinoma;Estrogen signaling pathway;VEGF signaling pathway;Osteoclast differentiation;Glioma;Epstein-Barr virus infection; Focal adhesion;Tight junction;Hepatitis C;Fc gamma R-mediated phagocytosis;Pancreatic cancer;Acute myeloid leukemia;Adipocytokine signaling pathway
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Collectively, our findings established Linc00152 as a candidate prognostic indicator of outcome and drug responsiveness in colon cancer patients, and the involvement of competing endogenous RNAs mechanism in Linc00152/miR-193a-3p/ERBB4/AKT signaling axis may provide a novel choice in the investigation of drug resistance.
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Linc00153 Functions as a Competing Endogenous RNA to Confer Oxaliplatin Resistance and Holds Prognostic Values in Colon Cancer
Colon Cancer Mol Ther 27633443
MALAT1 miR-22-3p AKT AKT2;HIHGHH;PKBB;PKBBETA;PRKBB;RAC-BETA details
Cholinergic synapse;HIF-1 signaling pathway;Chemokine signaling pathway;MAPK signaling pathway;Small cell lung cancer;Toll-like receptor signaling pathway;Fc epsilon RI signaling pathway;T cell receptor signaling pathway;ErbB signaling pathway;Carbohydrate digestion and absorption;Chagas disease (American trypanosomiasis);mTOR signaling pathway;PI3K-Akt signaling pathway;Hepatitis B;HTLV-I infection;Pathways in cancer;Toxoplasmosis;Colorectal cancer;Endometrial cancer;Jak-STAT signaling pathway;Neurotrophin signaling pathway;Influenza A;Proteoglycans in cancer; Measles;Dopaminergic synapse;Tuberculosis;Prostate cancer;Non-small cell lung cancer;Apoptosis;Progesterone-mediated oocyte maturation;Melanoma;Chronic myeloid leukemia; B cell receptor signaling pathway; Insulin signaling pathway;Renal cell carcinoma;Estrogen signaling pathway;VEGF signaling pathway;Osteoclast differentiation;Glioma;Epstein-Barr virus infection; Focal adhesion;Tight junction;Hepatitis C;Fc gamma R-mediated phagocytosis;Pancreatic cancer;Acute myeloid leukemia;Adipocytokine signaling pathway
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MALAT1 silencing significantly downregulated the expression of the miR-22-3p target gene CXCR2 via reversing the effect of the miR-22-3p, resulting in the aggravation of Oxidized low-density lipoprotein (ox-LDL)-induced endothelial injury; this process was associated with the AKT pathway.
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The lncRNA MALAT1 protects the endothelium against ox-LDL-induced dysfunction via upregulating the expression of the miR-22-3p target genes CXCR2 and AKT
Kidney Carcinoma FEBS Lett 26364720
XIST miR-494 AKT AKT1;AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA details
Cholinergic synapse;HIF-1 signaling pathway;Chemokine signaling pathway;MAPK signaling pathway;Small cell lung cancer;Toll-like receptor signaling pathway;Fc epsilon RI signaling pathway;T cell receptor signaling pathway;ErbB signaling pathway;Carbohydrate digestion and absorption;Chagas disease (American trypanosomiasis);mTOR signaling pathway;PI3K-Akt signaling pathway;Hepatitis B;HTLV-I infection;Pathways in cancer;Toxoplasmosis;Colorectal cancer;Endometrial cancer;Jak-STAT signaling pathway;Neurotrophin signaling pathway;Influenza A;Proteoglycans in cancer; Measles;Dopaminergic synapse;Tuberculosis;Prostate cancer;Non-small cell lung cancer;Apoptosis;Progesterone-mediated oocyte maturation;Melanoma;Chronic myeloid leukemia; B cell receptor signaling pathway; Insulin signaling pathway;Renal cell carcinoma;Estrogen signaling pathway;VEGF signaling pathway;Osteoclast differentiation;Glioma;Epstein-Barr virus infection; Focal adhesion;Tight junction;Hepatitis C;Fc gamma R-mediated phagocytosis;Pancreatic cancer;Acute myeloid leukemia;Adipocytokine signaling pathway
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In particular, our results suggested that lncRNA-XIST may act as a competitive endogenous RNA, effectively becoming a sink for miR-494, leading to derepression of its target gene, phosphatase and tensin homolog deleted on chromosome ten (PTEN). In addition, an inverse relationship between lncRNA-XIST and miR-494 was observed in spinal cord tissues of SCI rats. Further study demonstrated that antagomiR-494 could reverse the protective effects of lncRNA-XIST knockdown on SCI rats through blocking the PTEN/PI3K/AKT signaling pathway.
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Long Coding RNA XIST Contributes to Neuronal Apoptosis through the Downregulation of AKT Phosphorylation and Is Negatively Regulated by miR-494 in Rat Spinal Cord Injury
Spinal Cord Injury Int J Mol Sci 28368292
ciRS-7 miR-7 AKT AKT1;AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA details
Cholinergic synapse;HIF-1 signaling pathway;Chemokine signaling pathway;MAPK signaling pathway;Small cell lung cancer;Toll-like receptor signaling pathway;Fc epsilon RI signaling pathway;T cell receptor signaling pathway;ErbB signaling pathway;Carbohydrate digestion and absorption;Chagas disease (American trypanosomiasis);mTOR signaling pathway;PI3K-Akt signaling pathway;Hepatitis B;HTLV-I infection;Pathways in cancer;Toxoplasmosis;Colorectal cancer;Endometrial cancer;Jak-STAT signaling pathway;Neurotrophin signaling pathway;Influenza A;Proteoglycans in cancer; Measles;Dopaminergic synapse;Tuberculosis;Prostate cancer;Non-small cell lung cancer;Apoptosis;Progesterone-mediated oocyte maturation;Melanoma;Chronic myeloid leukemia; B cell receptor signaling pathway; Insulin signaling pathway;Renal cell carcinoma;Estrogen signaling pathway;VEGF signaling pathway;Osteoclast differentiation;Glioma;Epstein-Barr virus infection; Focal adhesion;Tight junction;Hepatitis C;Fc gamma R-mediated phagocytosis;Pancreatic cancer;Acute myeloid leukemia;Adipocytokine signaling pathway
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Furthermore, overexpression of ciRS-7 blocked the miR-7-induced tumor suppression in MGC-803 and HGC-27 cells and led to a more aggressive oncogenic phenotype, via antagonizing miR-7-mediated PTEN/PI3K/AKT pathway.
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Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway.
Gastric cancer J Cell Biochem 28608528
SNHG6-003 miR-26a AKT1 AKT1;AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA details
Apoptosis;MAPK signaling pathway;Acute myeloid leukemia;ErbB signaling pathway;Chemokine signaling pathway;Fc gamma R-mediated phagocytosis;Insulin signaling pathway;Pathways in cancer;Melanoma;Dopaminergic synapse;Colorectal cancer;Estrogen signaling pathway;HTLV-I infection;Toll-like receptor signaling pathway;Glioma;Adipocytokine signaling pathway;HIF-1 signaling pathway;Jak-STAT signaling pathway;Proteoglycans in cancer;Toxoplasmosis;B cell receptor signaling pathway;Small cell lung cancer;Progesterone-mediated oocyte maturation;Non-small cell lung cancer;Measles;Fc epsilon RI signaling pathway;mTOR signaling pathway;PI3K-Akt signaling pathway;Chagas disease (American trypanosomiasis);Hepatitis C;VEGF signaling pathway;Prostate cancer;Renal cell carcinoma;Tuberculosis;Influenza A;T cell receptor signaling pathway;Osteoclast differentiation;Carbohydrate digestion and absorption; Endometrial cancer;Pancreatic cancer;Chronic myeloid leukemia;Cholinergic synapse;Hepatitis B;Focal adhesion;Epstein-Barr virus infection; Neurotrophin signaling pathway;Tight junction
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Moreover, SNHG6-003 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-26a/b and thereby modulating the expression of transforming growth factor-β-activated kinase 1 (TAK1).
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The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma
Hepatocellular Carcinoma ONCOGENE 27530352
SNHG6-003 miR-26b AKT1 AKT1;AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA details
Apoptosis;MAPK signaling pathway;Acute myeloid leukemia;ErbB signaling pathway;Chemokine signaling pathway;Fc gamma R-mediated phagocytosis;Insulin signaling pathway;Pathways in cancer;Melanoma;Dopaminergic synapse;Colorectal cancer;Estrogen signaling pathway;HTLV-I infection;Toll-like receptor signaling pathway;Glioma;Adipocytokine signaling pathway;HIF-1 signaling pathway;Jak-STAT signaling pathway;Proteoglycans in cancer;Toxoplasmosis;B cell receptor signaling pathway;Small cell lung cancer;Progesterone-mediated oocyte maturation;Non-small cell lung cancer;Measles;Fc epsilon RI signaling pathway;mTOR signaling pathway;PI3K-Akt signaling pathway;Chagas disease (American trypanosomiasis);Hepatitis C;VEGF signaling pathway;Prostate cancer;Renal cell carcinoma;Tuberculosis;Influenza A;T cell receptor signaling pathway;Osteoclast differentiation;Carbohydrate digestion and absorption; Endometrial cancer;Pancreatic cancer;Chronic myeloid leukemia;Cholinergic synapse;Hepatitis B;Focal adhesion;Epstein-Barr virus infection; Neurotrophin signaling pathway;Tight junction
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Moreover, SNHG6-003 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-26a/b and thereby modulating the expression of transforming growth factor-β-activated kinase 1 (TAK1).
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The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma
Hepatocellular Carcinoma ONCOGENE 27530352
H19 miR-194-5p AKT2 AKT2;:HIHGHH;PKBB;PKBBETA;PRKBB;RAC-BETA details
Dopaminergic synapse;ErbB signaling pathway;MAPK signaling pathway;Prostate cancer;Pathways in cancer;Melanoma;Pancreatic cancer;Chemokine signaling pathway;Fc epsilon RI signaling pathway;HIF-1 signaling pathway;Progesterone-mediated oocyte maturation;Colorectal cancer;HTLV-I infection;mTOR signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Epstein-Barr virus infection;Proteoglycans in cancer;Influenza A;Cholinergic synapse;Fc gamma R-mediated phagocytosis;Neurotrophin signaling pathway;Jak-STAT signaling pathway;T cell receptor signaling pathway;Acute myeloid leukemia;Glioma;Small cell lung cancer;Non-small cell lung cancer;PI3K-Akt signaling pathway; Apoptosis;VEGF signaling pathway;Hepatitis C;Carbohydrate digestion and absorption;Chagas disease (American trypanosomiasis);Measles;Adipocytokine signaling pathway;Tuberculosis; Osteoclast differentiation;B cell receptor signaling pathway;Hepatitis B;Focal adhesion;Estrogen signaling pathway;Insulin signaling pathway;Tight junction;Endometrial cancer;Chronic myeloid leukemia;Renal cell carcinoma
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In addition, overexpression of H19 in GBC-SD cells downregulated miR-194-5p and markedly increased AKT2 expression, and miR-194-5p mimic reversed these effects.
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Long noncoding RNA H19 contributes to gallbladder cancer cell proliferation by modulated miR-194-5p targeting AKT2
Gallbladder Cancer Tumour Biol 26803515
ZNF609 miR-150-5p AKT3 AKT3;MPPH;MPPH2;PKB-GAMMA;PKBG;PRKBG;RAC-PK-gamma;RAC-gamma;STK-2 details
Chemokine signaling pathway;MAPK signaling pathway;Neurotrophin signaling pathway;Colorectal cancer;Insulin signaling pathway;Pancreatic cancer; Chronic myeloid leukemia;Epstein-Barr virus infection;ErbB signaling pathway;HIF-1 signaling pathway; B cell receptor signaling pathway;Tuberculosis;Prostate cancer;Fc epsilon RI signaling pathway;Renal cell carcinoma;T cell receptor signaling pathway;Progesterone-mediated oocyte maturation; Glioma;Chagas disease (American trypanosomiasis);mTOR signaling pathway; PI3K-Akt signaling pathway;Hepatitis B;Toll-like receptor signaling pathway;HTLV-I infection;Small cell lung cancer; Pathways in cancer;Apoptosis;Hepatitis C; Influenza A;Adipocytokine signaling pathway;Carbohydrate digestion and absorption;Melanoma;Toxoplasmosis;Proteoglycans in cancer;VEGF signaling pathway;Osteoclast differentiation; Jak-STAT signaling pathway;Endometrial cancer;Measles;Acute myeloid leukemia;Non-small cell lung cancer;Focal adhesion;Estrogen signaling pathway;Dopaminergic synapse;Fc gamma R-mediated phagocytosis;Cholinergic synapse; Tight junction
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In conclusion, these findings illustrated that cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p.
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Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease
Hirschsprung'S Disease Oncotarget 27903978