Cholinergic synapse；HIF-1 signaling pathway；Chemokine signaling pathway；MAPK signaling pathway；Small cell lung cancer；Toll-like receptor signaling pathway；Fc epsilon RI signaling pathway；T cell receptor signaling pathway；ErbB signaling pathway；Carbohydrate digestion and absorption；Chagas disease (American trypanosomiasis)；mTOR signaling pathway；PI3K-Akt signaling pathway；Hepatitis B；HTLV-I infection；Pathways in cancer；Toxoplasmosis；Colorectal cancer；Endometrial cancer；Jak-STAT signaling pathway；Neurotrophin signaling pathway；Influenza A；Proteoglycans in cancer； Measles；Dopaminergic synapse；Tuberculosis；Prostate cancer；Non-small cell lung cancer；Apoptosis；Progesterone-mediated oocyte maturation；Melanoma；Chronic myeloid leukemia； B cell receptor signaling pathway； Insulin signaling pathway；Renal cell carcinoma；Estrogen signaling pathway；VEGF signaling pathway；Osteoclast differentiation；Glioma；Epstein-Barr virus infection； Focal adhesion；Tight junction；Hepatitis C；Fc gamma R-mediated phagocytosis；Pancreatic cancer；Acute myeloid leukemia；Adipocytokine signaling pathway

The exposure levels of the proteins related to the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) axis, including AKT, mTOR, and S6K1, were measured by western blot PC3 cells infected with lncRNA GAS5 mimic； lncRNA GAS5 siRNA； or a combination of lncRNA and miR-103.

LncRNA GAS5 inhibits proliferation and progression of prostate cancer by targeting miR-103 through AKT/mTOR signaling pathway

Cholinergic synapse；HIF-1 signaling pathway；Chemokine signaling pathway；MAPK signaling pathway；Small cell lung cancer；Toll-like receptor signaling pathway；Fc epsilon RI signaling pathway；T cell receptor signaling pathway；ErbB signaling pathway；Carbohydrate digestion and absorption；Chagas disease (American trypanosomiasis)；mTOR signaling pathway；PI3K-Akt signaling pathway；Hepatitis B；HTLV-I infection；Pathways in cancer；Toxoplasmosis；Colorectal cancer；Endometrial cancer；Jak-STAT signaling pathway；Neurotrophin signaling pathway；Influenza A；Proteoglycans in cancer； Measles；Dopaminergic synapse；Tuberculosis；Prostate cancer；Non-small cell lung cancer；Apoptosis；Progesterone-mediated oocyte maturation；Melanoma；Chronic myeloid leukemia； B cell receptor signaling pathway； Insulin signaling pathway；Renal cell carcinoma；Estrogen signaling pathway；VEGF signaling pathway；Osteoclast differentiation；Glioma；Epstein-Barr virus infection； Focal adhesion；Tight junction；Hepatitis C；Fc gamma R-mediated phagocytosis；Pancreatic cancer；Acute myeloid leukemia；Adipocytokine signaling pathway

Collectively, our findings established Linc00152 as a candidate prognostic indicator of outcome and drug responsiveness in colon cancer patients, and the involvement of competing endogenous RNAs mechanism in Linc00152/miR-193a-3p/ERBB4/AKT signaling axis may provide a novel choice in the investigation of drug resistance.

Linc00153 Functions as a Competing Endogenous RNA to Confer Oxaliplatin Resistance and Holds Prognostic Values in Colon Cancer

Cholinergic synapse；HIF-1 signaling pathway；Chemokine signaling pathway；MAPK signaling pathway；Small cell lung cancer；Toll-like receptor signaling pathway；Fc epsilon RI signaling pathway；T cell receptor signaling pathway；ErbB signaling pathway；Carbohydrate digestion and absorption；Chagas disease (American trypanosomiasis)；mTOR signaling pathway；PI3K-Akt signaling pathway；Hepatitis B；HTLV-I infection；Pathways in cancer；Toxoplasmosis；Colorectal cancer；Endometrial cancer；Jak-STAT signaling pathway；Neurotrophin signaling pathway；Influenza A；Proteoglycans in cancer； Measles；Dopaminergic synapse；Tuberculosis；Prostate cancer；Non-small cell lung cancer；Apoptosis；Progesterone-mediated oocyte maturation；Melanoma；Chronic myeloid leukemia； B cell receptor signaling pathway； Insulin signaling pathway；Renal cell carcinoma；Estrogen signaling pathway；VEGF signaling pathway；Osteoclast differentiation；Glioma；Epstein-Barr virus infection； Focal adhesion；Tight junction；Hepatitis C；Fc gamma R-mediated phagocytosis；Pancreatic cancer；Acute myeloid leukemia；Adipocytokine signaling pathway

MALAT1 silencing significantly downregulated the expression of the miR-22-3p target gene CXCR2 via reversing the effect of the miR-22-3p, resulting in the aggravation of Oxidized low-density lipoprotein (ox-LDL)-induced endothelial injury； this process was associated with the AKT pathway.

The lncRNA MALAT1 protects the endothelium against ox-LDL-induced dysfunction via upregulating the expression of the miR-22-3p target genes CXCR2 and AKT

Cholinergic synapse；HIF-1 signaling pathway；Chemokine signaling pathway；MAPK signaling pathway；Small cell lung cancer；Toll-like receptor signaling pathway；Fc epsilon RI signaling pathway；T cell receptor signaling pathway；ErbB signaling pathway；Carbohydrate digestion and absorption；Chagas disease (American trypanosomiasis)；mTOR signaling pathway；PI3K-Akt signaling pathway；Hepatitis B；HTLV-I infection；Pathways in cancer；Toxoplasmosis；Colorectal cancer；Endometrial cancer；Jak-STAT signaling pathway；Neurotrophin signaling pathway；Influenza A；Proteoglycans in cancer； Measles；Dopaminergic synapse；Tuberculosis；Prostate cancer；Non-small cell lung cancer；Apoptosis；Progesterone-mediated oocyte maturation；Melanoma；Chronic myeloid leukemia； B cell receptor signaling pathway； Insulin signaling pathway；Renal cell carcinoma；Estrogen signaling pathway；VEGF signaling pathway；Osteoclast differentiation；Glioma；Epstein-Barr virus infection； Focal adhesion；Tight junction；Hepatitis C；Fc gamma R-mediated phagocytosis；Pancreatic cancer；Acute myeloid leukemia；Adipocytokine signaling pathway

In particular, our results suggested that lncRNA-XIST may act as a competitive endogenous RNA, effectively becoming a sink for miR-494, leading to derepression of its target gene, phosphatase and tensin homolog deleted on chromosome ten (PTEN). In addition, an inverse relationship between lncRNA-XIST and miR-494 was observed in spinal cord tissues of SCI rats. Further study demonstrated that antagomiR-494 could reverse the protective effects of lncRNA-XIST knockdown on SCI rats through blocking the PTEN/PI3K/AKT signaling pathway.

Long Coding RNA XIST Contributes to Neuronal Apoptosis through the Downregulation of AKT Phosphorylation and Is Negatively Regulated by miR-494 in Rat Spinal Cord Injury

Cholinergic synapse；HIF-1 signaling pathway；Chemokine signaling pathway；MAPK signaling pathway；Small cell lung cancer；Toll-like receptor signaling pathway；Fc epsilon RI signaling pathway；T cell receptor signaling pathway；ErbB signaling pathway；Carbohydrate digestion and absorption；Chagas disease (American trypanosomiasis)；mTOR signaling pathway；PI3K-Akt signaling pathway；Hepatitis B；HTLV-I infection；Pathways in cancer；Toxoplasmosis；Colorectal cancer；Endometrial cancer；Jak-STAT signaling pathway；Neurotrophin signaling pathway；Influenza A；Proteoglycans in cancer； Measles；Dopaminergic synapse；Tuberculosis；Prostate cancer；Non-small cell lung cancer；Apoptosis；Progesterone-mediated oocyte maturation；Melanoma；Chronic myeloid leukemia； B cell receptor signaling pathway； Insulin signaling pathway；Renal cell carcinoma；Estrogen signaling pathway；VEGF signaling pathway；Osteoclast differentiation；Glioma；Epstein-Barr virus infection； Focal adhesion；Tight junction；Hepatitis C；Fc gamma R-mediated phagocytosis；Pancreatic cancer；Acute myeloid leukemia；Adipocytokine signaling pathway

Furthermore, overexpression of ciRS-7 blocked the miR-7-induced tumor suppression in MGC-803 and HGC-27 cells and led to a more aggressive oncogenic phenotype, via antagonizing miR-7-mediated PTEN/PI3K/AKT pathway.

Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway.

Apoptosis；MAPK signaling pathway；Acute myeloid leukemia；ErbB signaling pathway；Chemokine signaling pathway；Fc gamma R-mediated phagocytosis；Insulin signaling pathway；Pathways in cancer；Melanoma；Dopaminergic synapse；Colorectal cancer；Estrogen signaling pathway；HTLV-I infection；Toll-like receptor signaling pathway；Glioma；Adipocytokine signaling pathway；HIF-1 signaling pathway；Jak-STAT signaling pathway；Proteoglycans in cancer；Toxoplasmosis；B cell receptor signaling pathway；Small cell lung cancer；Progesterone-mediated oocyte maturation；Non-small cell lung cancer；Measles；Fc epsilon RI signaling pathway；mTOR signaling pathway；PI3K-Akt signaling pathway；Chagas disease (American trypanosomiasis)；Hepatitis C；VEGF signaling pathway；Prostate cancer；Renal cell carcinoma；Tuberculosis；Influenza A；T cell receptor signaling pathway；Osteoclast differentiation；Carbohydrate digestion and absorption； Endometrial cancer；Pancreatic cancer；Chronic myeloid leukemia；Cholinergic synapse；Hepatitis B；Focal adhesion；Epstein-Barr virus infection； Neurotrophin signaling pathway；Tight junction

Moreover, SNHG6-003 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-26a/b and thereby modulating the expression of transforming growth factor-β-activated kinase 1 (TAK1).

The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma

Apoptosis；MAPK signaling pathway；Acute myeloid leukemia；ErbB signaling pathway；Chemokine signaling pathway；Fc gamma R-mediated phagocytosis；Insulin signaling pathway；Pathways in cancer；Melanoma；Dopaminergic synapse；Colorectal cancer；Estrogen signaling pathway；HTLV-I infection；Toll-like receptor signaling pathway；Glioma；Adipocytokine signaling pathway；HIF-1 signaling pathway；Jak-STAT signaling pathway；Proteoglycans in cancer；Toxoplasmosis；B cell receptor signaling pathway；Small cell lung cancer；Progesterone-mediated oocyte maturation；Non-small cell lung cancer；Measles；Fc epsilon RI signaling pathway；mTOR signaling pathway；PI3K-Akt signaling pathway；Chagas disease (American trypanosomiasis)；Hepatitis C；VEGF signaling pathway；Prostate cancer；Renal cell carcinoma；Tuberculosis；Influenza A；T cell receptor signaling pathway；Osteoclast differentiation；Carbohydrate digestion and absorption； Endometrial cancer；Pancreatic cancer；Chronic myeloid leukemia；Cholinergic synapse；Hepatitis B；Focal adhesion；Epstein-Barr virus infection； Neurotrophin signaling pathway；Tight junction

Moreover, SNHG6-003 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-26a/b and thereby modulating the expression of transforming growth factor-β-activated kinase 1 (TAK1).

The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma

Dopaminergic synapse；ErbB signaling pathway；MAPK signaling pathway；Prostate cancer；Pathways in cancer；Melanoma；Pancreatic cancer；Chemokine signaling pathway；Fc epsilon RI signaling pathway；HIF-1 signaling pathway；Progesterone-mediated oocyte maturation；Colorectal cancer；HTLV-I infection；mTOR signaling pathway；Toll-like receptor signaling pathway；Toxoplasmosis；Epstein-Barr virus infection；Proteoglycans in cancer；Influenza A；Cholinergic synapse；Fc gamma R-mediated phagocytosis；Neurotrophin signaling pathway；Jak-STAT signaling pathway；T cell receptor signaling pathway；Acute myeloid leukemia；Glioma；Small cell lung cancer；Non-small cell lung cancer；PI3K-Akt signaling pathway； Apoptosis；VEGF signaling pathway；Hepatitis C；Carbohydrate digestion and absorption；Chagas disease (American trypanosomiasis)；Measles；Adipocytokine signaling pathway；Tuberculosis； Osteoclast differentiation；B cell receptor signaling pathway；Hepatitis B；Focal adhesion；Estrogen signaling pathway；Insulin signaling pathway；Tight junction；Endometrial cancer；Chronic myeloid leukemia；Renal cell carcinoma

In addition, overexpression of H19 in GBC-SD cells downregulated miR-194-5p and markedly increased AKT2 expression, and miR-194-5p mimic reversed these effects.

Long noncoding RNA H19 contributes to gallbladder cancer cell proliferation by modulated miR-194-5p targeting AKT2

Chemokine signaling pathway；MAPK signaling pathway；Neurotrophin signaling pathway；Colorectal cancer；Insulin signaling pathway；Pancreatic cancer； Chronic myeloid leukemia；Epstein-Barr virus infection；ErbB signaling pathway；HIF-1 signaling pathway； B cell receptor signaling pathway；Tuberculosis；Prostate cancer；Fc epsilon RI signaling pathway；Renal cell carcinoma；T cell receptor signaling pathway；Progesterone-mediated oocyte maturation； Glioma；Chagas disease (American trypanosomiasis)；mTOR signaling pathway； PI3K-Akt signaling pathway；Hepatitis B；Toll-like receptor signaling pathway；HTLV-I infection；Small cell lung cancer； Pathways in cancer；Apoptosis；Hepatitis C； Influenza A；Adipocytokine signaling pathway；Carbohydrate digestion and absorption；Melanoma；Toxoplasmosis；Proteoglycans in cancer；VEGF signaling pathway；Osteoclast differentiation； Jak-STAT signaling pathway；Endometrial cancer；Measles；Acute myeloid leukemia；Non-small cell lung cancer；Focal adhesion；Estrogen signaling pathway；Dopaminergic synapse；Fc gamma R-mediated phagocytosis；Cholinergic synapse； Tight junction

In conclusion, these findings illustrated that cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p.

Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease