LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
circ_0009910 | miR-449a | IL6R | IL6R;CD126;IL-6R-1;IL-6RA;IL6Q;IL6RA;IL6RQ;gp80 | details
Cytokine-cytokine receptor interaction;HIF-1 signaling pathway;PI3K-Akt signaling pathway;Jak-STAT signaling pathway;Hematopoietic cell lineage
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Direct interaction of circ_0009910 and miR-449a was confirmed through dual-luciferase assays. Moreover, IL6R was predicted as a potential target of miR-449a. Overexpression of miR-449a decreased the mRNA and protein levels of IL6R.
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Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma
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Osteosarcoma | Biochem Biophys Res Commun | 29117539 |