LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
Malat1 | miR-101 | RAB5A | RAB5A;RAB5 | details
Endocytosis;Phagosome;Vasopressin-regulated water reabsorption;Amyotrophic lateral sclerosis (ALS);Amoebiasis;Tuberculosis
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We further investigated the molecular mechanisms whereby Malat1 functioned on glioma cell autophagy and proliferation. We found that Malat1 served as an endogenous sponge to reduce miR-101 expression by directly binding to miR-101. Moreover, Malat1 abolished the suppression effects of miR-101 on glioma cell autophagy and proliferation, which involved in upregulating the expression of miR-101 targets STMN1, RAB5A and ATG4D.
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Malat1 activates autophagy and promotes cell proliferation by sponging miR-101 and upregulating STMN1, RAB5A and ATG4D expression in glioma.
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Glioma | Biochem Biophys Res Commun | 28834690 |