LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
NEAT1 | miR-107 | CDK6 | CDK6;MCPH12;PLSTIRE | details
Hepatitis B;Cell cycle;p53 signaling pathway;PI3K-Akt signaling pathway;Measles;Pathways in cancer; Small cell lung cancer;Non-small cell lung cancer;Viral carcinogenesis;Pancreatic cancer;Glioma;Melanoma;Chronic myeloid leukemia
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Furthermore, NEAT1 regulated CDK6 expression in LSCC cells which was mediated by miR-107.
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Long noncoding RNA NEAT1 promotes laryngeal squamous cell cancer through regulating miR-107/CDK6 pathway
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Laryngeal Squamous Cell Cancer | J Exp Clin Cancer Res | 26822763 |
HULC | miR-107 | E2F1 | E2F1;E2F-1;RBAP1;RBBP3;RBP3 | details
HTLV-I infection;Cell cycle;Hepatitis B;Non-small cell lung cancer;Pathways in cancer;Pancreatic cancer;Glioma;Prostate cancer;Melanoma;Bladder cancer;Chronic myeloid leukemia;Small cell lung cancer
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HULC increased the expression of E2F1 in hepatoma cells and levels of HULC were positively correlated with those of E2F1 in HCC tissues. Intriguingly, HULC sequestered miR-107, which targeted E2F1 mRNA 3'UTR, by complementary base pairing.
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Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)
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Liver Cancer | Oncotarget | 26540633 |
HULC | miR-107 | SPHK1 | SPHK1;SPHK | details
Sphingolipid metabolism;Metabolic pathways;Calcium signaling pathway;VEGF signaling pathway;Fc gamma R-mediated phagocytosis;Tuberculosis
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Taken together, we conclude that HULC promotes tumor angiogenesis in liver cancer through miR-107/E2F1/SPHK1 signaling. Our finding provides new insights into the mechanism of tumor angiogenesis.
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Long non-coding RNA HULC promotes tumor angiogenesis in liver cancer by up-regulating sphingosine kinase 1 (SPHK1)
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Liver Cancer | Oncotarget | 26540633 |