Cytokine-cytokine receptor interaction；Endocytosis；PI3K-Akt signaling pathway；Axon guidance；Focal adhesion；Adherens junction；Bacterial invasion of epithelial cells；Proteoglycans in cancer；Renal cell carcinoma；Melanoma；Epithelial cell signaling in Helicobacter pylori infection；Malaria；Pathways in cancer；Transcriptional misregulation in cancer

We isolated cells from the primary mammary tumor, the circulation, and metastatic lesions in the lung in TA2 mice and found that the long noncoding RNA (lncRNA) H19 mediated EMT and MET by differentially acting as a sponge for the microRNAs miR-200b/c and let-7b.

The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b.

Hippo signaling pathway；MAPK signaling pathway；Cytokine-cytokine receptor interaction；Cell cycle；Endocytosis；TGF-beta signaling pathway；Renal cell carcinoma；Hypertrophic cardiomyopathy (HCM)；Chronic myeloid leukemia；Toxoplasmosis；Pathways in cancer；Osteoclast differentiation；HTLV-I infection；Proteoglycans in cancer；Intestinal immune network for IgA production；Rheumatoid arthritis；Dilated cardiomyopathy；Hepatitis B；Pancreatic cancer；Leishmaniasis；Tuberculosis；Chagas disease (American trypanosomiasis)；Colorectal cancer； Malaria

MALAT1 and miR-200c are reciprocally repressed, and TGF-β increased MALAT1 expression by inhibiting miR-200c.

Disrupting MALAT1/miR-200c sponge decreases invasion and migration in endometrioid endometrial carcinoma

NF-kappa B signaling pathway；Ubiquitin mediated proteolysis；Apoptosis；Focal adhesion；Toxoplasmosis；HTLV-I infection；Pathways in cancer；Small cell lung cancer

CircVMA21 could alleviate inflammatory cytokines-induced NP cell apoptosis and imbalance between anabolism and catabolism of extracellular matrix through miR-200c-XIAP pathway. It provides a potentially effective therapeutic strategy for IVDD.

Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein

Transcriptional misregulation in cancer

Furthermore, we showed that H19 promotes metastasis through upregulation of ZEB1 and ZEB2 by competitively binding the miR-200 family.

H19 Functions as a ceRNA in Promoting Metastasis Through Decreasing miR-200s Activity in Osteosarcoma

Transcriptional misregulation in cancer

Collectively, silica-stimulated macrophages secreted TGF-β1 to induce lncRNA-ATB in epithelia cells, promoting EMT by binding with miR-200c and releasing ZEB1

Long non-coding RNA-ATB promotes EMT during silica-induced pulmonary fibrosis by competitively binding miR-200c.

Furthermore, we showed that H19 promotes metastasis through upregulation of ZEB1 and ZEB2 by competitively binding the miR-200 family.

H19 Functions as a ceRNA in Promoting Metastasis Through Decreasing miR-200s Activity in Osteosarcoma

We further demonstrated MALAT1 promote KIRC proliferation and metastasis through sponging miR-200s in vitro and in vivo. In addition, miR-200c can partly reverse the MALAT1's stimulation on proliferation and metastasis in KIRC. In summary we unveil a branch of the MALAT1/miR-200s/ZEB2 pathway that regulates the progression of KIRC.

LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma

Using immunohistochemistry and quantitative RT-PCR analysis, we showed that lncRNA-ATB and ZNF217, a transcriptional activator of TGF-β, were overexpressed and miR-200c, which targets ZNF217, was under-expressed in keloid tissue and keloid fibroblasts.

Knockdown of lncRNA-ATB suppresses autocrine secretion of TGF-β2 by targeting ZNF217 via miR-200c in keloid fibroblasts