LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
HOTAIR | miR-19 | PTEN | PTEN;10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;TEP1 | details
p53 signaling pathway;Inositol phosphate metabolism;Prostate cancer;Phosphatidylinositol signaling system;mTOR signaling pathway;PI3K-Akt signaling pathway;Focal adhesion;Tight junction;Hepatitis B;Pathways in cancer;Melanoma;Endometrial cancer;Glioma;Small cell lung cancer
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The further molecular mechanisms of HOTAIR action in CH demonstrated that HOTAIR may act as a competing endogenous RNA (ceRNA) for miR-19, thereby modulating the dis-inhibition of its endogenous target PTEN and playing an important role in inhibiting CH progress.
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HOTAIR functions as a competing endogenous RNA to regulate PTEN expression by inhibiting miR-19 in cardiac hypertrophy
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Cardiac Hypertrophy | Mol Cell Biochem | 28316060 |
PTENP1 | miR-19 | PTEN | PTEN;10q23del;BZS;CWS1;DEC;GLM2;MHAM;MMAC1;PTEN1;TEP1 | details
p53 signaling pathway;Inositol phosphate metabolism;Prostate cancer;Phosphatidylinositol signaling system;mTOR signaling pathway;PI3K-Akt signaling pathway;Focal adhesion;Tight junction;Hepatitis B;Pathways in cancer;Melanoma;Endometrial cancer;Glioma;Small cell lung cancer
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In DU145 prostate cancer cells, PTEN-targeting microRNAs miR-19b and miR-20a suppress both PTEN and PTENP1 mRNA abundance
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A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
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Prostate Cancer | Nature | 20577206 |