LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
UCA1 | miR-196a-5p | CREB | CREB1;CREB | details
Dopaminergic synapse;PI3K-Akt signaling pathway;HTLV-I infection;Huntington's disease;Hepatitis B;Osteoclast differentiation;Antigen processing and presentation;Circadian rhythm;Alcoholism;Circadian entrainment;Cholinergic synapse;Prostate cancer;Viral carcinogenesis;Cocaine addiction;Tuberculosis;Insulin secretion;Estrogen signaling pathway;Melanogenesis;Amphetamine addiction;Vasopressin-regulated water reabsorption
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Moreover, UCA1 activated transcription factor CREB which led to miR-196a-5p expression by binding with its promoter. miR-196a-5p induction is involved in UCA1 inhibition of apoptosis induced by cisplatin/gemcitabine via targeting p27Kip1
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Long non-coding RNA UCA1 promotes cisplatin/gemcitabine resistance through CREB modulating miR-196a-5p in bladder cancer cells
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Bladder Cancer | Cancer Lett | 27591936 |