NF-kappa B signaling pathway；MAPK signaling pathway；Ubiquitin mediated proteolysis；Endocytosis；Chagas disease (American trypanosomiasis)；Osteoclast differentiation；Toll-like receptor signaling pathway；Herpes simplex infection；NOD-like receptor signaling pathway；Hepatitis C；RIG-I-like receptor signaling pathway；Neurotrophin signaling pathway； Toxoplasmosis；Measles；Pertussis；Leishmaniasis；Tuberculosis；Small cell lung cancer；Epstein-Barr virus infection；Pathways in cancer

Remarkably, TNF receptor associated factor 6 (TRAF6) was confirmed as a direct target of miR-146b-5p in HCC and miR-146b-5p exerted the tumor suppression roles through inhibiting the phosphorylation of Akt mediated by TRAF6. Furthermore, we identified long non-coding RNA MALAT1 as a molecular sponge of miR-146b-5p to down-regulate its expression in HCC.

Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis

Endocytosis；MAPK signaling pathway；NF-kappa B signaling pathway；Ubiquitin mediated proteolysis；Osteoclast differentiation；Chagas disease (American trypanosomiasis)；Small cell lung cancer；Measles； Toxoplasmosis；Tuberculosis；Toll-like receptor signaling pathway；Pathways in cancer；NOD-like receptor signaling pathway；RIG-I-like receptor signaling pathway；Neurotrophin signaling pathway； Hepatitis C；Pertussis；Epstein-Barr virus infection；Leishmaniasis；Herpes simplex infection

Remarkably, TNF receptor associated factor 6 (TRAF6) was confirmed as a direct target of miR-146b-5p in HCC and miR-146b-5p exerted the tumor suppression roles through inhibiting the phosphorylation of Akt mediated by TRAF6. Furthermore, we identified long non-coding RNA MALAT1 as a molecular sponge of miR-146b-5p to down-regulate its expression in HCC.

Down-regulation of miR-146b-5p by long noncoding RNA MALAT1 in hepatocellular carcinoma promotes cancer growth and metastasis.