| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| PVT1 | miR-186 | Twist1 | TWIST1；ACS3；BPES2；BPES3；CRS；CRS1；CSO；SCS；TWIST；bHLHa38 | details
Proteoglycans in cancer
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We then confirmed that PVT1 acts as a sponge for miRNA-186-5p and positively regulates Twist1 by a sponge effect. Therefore, this study has revealed a novel MECHANISM for the promotion of EMT in prostate cancer by PVT1. Our findings suggest that the PVT1/miR-186/Twist1 regulatory axis may be a new therapeutic target for prostate cancer.
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Long noncoding RNA PVT1 promotes EMT via mediating microRNA-186 targeting of Twist1 in prostate cancer
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Prostate cancer | Gene | 29452232 |
| ASLNC02525 | miR-489-3p | twist1 | TWIST1；ACS3；BPES2；BPES3；CRS；CRS1；CSO；SCS；TWIST；bHLHa38 | details | details
The mechanism study revealed that ASLNC02525, as an RNA sponge, broke the negative regulation of twist1 by hsa-miRNA-489-3p, and once ASLNC02525 was silenced, the highly expressed hsa-miRNA?489-3p regained its regulation on twist1 and inhibited the proliferation and invasion.
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Inhibition of proliferation and invasion of hepatocellular carcinoma cells by lncRNA-ASLNC02525 silencing and the mechanism.
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Hepatocellular carcinoma | Int J Oncol | 28713968 |