B cell receptor signaling pathway；HIF-1 signaling pathway；ErbB signaling pathway；Chemokine signaling pathway；Melanoma；Pancreatic cancer；Jak-STAT signaling pathway；Chronic myeloid leukemia；Estrogen signaling pathway；Carbohydrate digestion and absorption；Leukocyte transendothelial migration；Phosphatidylinositol signaling system；Hepatitis C；Pathways in cancer；T cell receptor signaling pathway； Progesterone-mediated oocyte maturation；Chagas disease (American trypanosomiasis)；Epstein-Barr virus infection；Bacterial invasion of epithelial cells；mTOR signaling pathway；PI3K-Akt signaling pathway；Apoptosis；Regulation of actin cytoskeleton；Non-small cell lung cancer；Insulin signaling pathway；Influenza A；Cholinergic synapse；Endometrial cancer；Aldosterone-regulated sodium reabsorption； Prostate cancer；Natural killer cell mediated cytotoxicity；Colorectal cancer；Amoebiasis；Viral carcinogenesis； Measles；VEGF signaling pathway；Fc gamma R-mediated phagocytosis；HTLV-I infection；Small cell lung cancer；Toxoplasmosis；Neurotrophin signaling pathway；Hepatitis B；Glioma；Type II diabetes mellitus；Fc epsilon RI signaling pathway；Renal cell carcinoma；Osteoclast differentiation；Focal adhesion；Acute myeloid leukemia；Proteoglycans in cancer；Toll-like receptor signaling pathway

Furthermore, HOTAIR was shown to directly bind to and inhibit miR-126 expression and then to promote VEGFA and PIK3R2 expression and activate the PI3K/AKT/MRP1 pathway.

LncRNA HOTAIR promotes cisplatin resistance in gastric cancer by targeting miR-126 to activate the PI3K/AKT/MRP1 genes

Chemokine signaling pathway；ErbB signaling pathway；Endometrial cancer； Renal cell carcinoma；HIF-1 signaling pathway；Phosphatidylinositol signaling system；mTOR signaling pathway；Aldosterone-regulated sodium reabsorption；Pancreatic cancer； Colorectal cancer；Insulin signaling pathway；Pathways in cancer；Small cell lung cancer；PI3K-Akt signaling pathway；Apoptosis；Bacterial invasion of epithelial cells；VEGF signaling pathway；Progesterone-mediated oocyte maturation；Prostate cancer；Fc epsilon RI signaling pathway；Epstein-Barr virus infection；Osteoclast differentiation；Focal adhesion；Fc gamma R-mediated phagocytosis；Regulation of actin cytoskeleton；Viral carcinogenesis；Glioma；HTLV-I infection；Leukocyte transendothelial migration；

Furthermore, HOTAIR was shown to directly bind to and inhibit miR-126 expression and then to promote VEGFA and PIK3R2 expression and activate the PI3K/AKT/MRP1 pathway.

LncRNA HOTAIR promotes cisplatin resistance in gastric cancer by targeting miR-126 to activate the PI3K/AKT/MRP1 genes