| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| ROR | miR-205 | ZEB1 | ZEB1；AREB6；BZP；DELTAEF1；FECD6；NIL2A；PPCD3；TCF8；ZFHEP；ZFHX1A | details
Transcriptional misregulation in cancer
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Compared with the MCF7 cells, the MCF7-ROR cells had remarkably higher proliferation rates, down-regulated E-cadherin and miR-205 expressions, as well as increased vimentin, invasive ability, and mRNA expression of ZEB1 and ZEB2. Compared with the MCF7/TR5 and MDA-MB-231 cells, up-regulated E-cadherin and miR-205 expression, down-regulated expression of vimentin, ZEB1, and ZEB2 mRNA, and decreased invasive ability were observed in the MCF7/TR5 ROR-siRNA and MDA-MB-231 ROR-siRNA cells.
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Effects of long noncoding RNA-ROR on tamoxifen resistance of breast cancer cells by regulating microRNA-205
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Breast Cancer | Cancer Chemother Pharmacol | 28063065 |
| ROR | miR-205 | ZEB2 | ZEB2；HSPC082；SIP-1；SIP1；SMADIP1；ZFHX1B | details | details
Specifically, linc-ROR prevented the degradation of mir-205 target genes, including the EMT inducer ZEB2.
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LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis
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Breast Cancer | Cell Death Dis | 24922071 |
| ROR | miR-205 | ZEB2 | ZEB2；HSPC082；SIP-1；SIP1；SMADIP1；ZFHX1B | details | details
Compared with the MCF7 cells, the MCF7-ROR cells had remarkably higher proliferation rates, down-regulated E-cadherin and miR-205 expressions, as well as increased vimentin, invasive ability, and mRNA expression of ZEB1 and ZEB2. Compared with the MCF7/TR5 and MDA-MB-231 cells, up-regulated E-cadherin and miR-205 expression, down-regulated expression of vimentin, ZEB1, and ZEB2 mRNA, and decreased invasive ability were observed in the MCF7/TR5 ROR-siRNA and MDA-MB-231 ROR-siRNA cells.
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details
Effects of long noncoding RNA-ROR on tamoxifen resistance of breast cancer cells by regulating microRNA-205
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Breast Cancer | Cancer Chemother Pharmacol | 28063065 |