LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
NEAT1 | miR-377-3p | E2F3 | E2F3;E2F-3 | details
Glioma;Cell cycle;Hepatitis B;HTLV-I infection;Pathways in cancer;Pancreatic cancer;Prostate cancer;Melanoma;Bladder cancer;Non-small cell lung cancer; Chronic myeloid leukemia;Small cell lung cancer
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Additionally, by using bioinformatics study and RNA pull down combined with luciferase reporter assays, we demonstrated that NEAT1 functioned as a competing endogenous RNA (ceRNA) for hsa-miR-377-3p, antagonized its functions and led to the de-repression of its endogenous targets E2F3, which was a core oncogene in promoting NSCLC progression.
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Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway
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Non-Small Cell Lung Cancer | Oncotarget | 27351135 |