HIF-1 signaling pathway；NF-kappa B signaling pathway；Protein processing in endoplasmic reticulum；Pathways in cancer；Small cell lung cancer；Prostate cancer；PI3K-Akt signaling pathway；Apoptosis；Focal adhesion； Neurotrophin signaling pathway；Cholinergic synapse；Amyotrophic lateral sclerosis (ALS)；Colorectal cancer；Hepatitis B；Epstein-Barr virus infection； Toxoplasmosis；Tuberculosis

Moreover, silencing PVT1 by siRNA inhibited BCL2, CCND1, and FASN protein expression via miR-195 in osteosarcoma cells, and BCL2 inhibited the si-PVT1#1-induced apoptosis of U2OS cells.

Long non-coding RNA PVT1 promotes osteosarcoma development by acting as a molecular sponge to regulate miR-195

Cell cycle；p53 signaling pathway；Endometrial cancer；Melanoma；Thyroid cancer；PI3K-Akt signaling pathway；Pancreatic cancer；Wnt signaling pathway；Hippo signaling pathway；Prostate cancer；Acute myeloid leukemia；Focal adhesion；Viral myocarditis；Viral carcinogenesis；Colorectal cancer；Jak-STAT signaling pathway；Hepatitis B；Measles；Proteoglycans in cancer；Bladder cancer；Non-small cell lung cancer；HTLV-I infection；Small cell lung cancer；Pathways in cancer；Glioma；Chronic myeloid leukemia

Moreover, silencing PVT1 by siRNA inhibited BCL2, CCND1, and FASN protein expression via miR-195 in osteosarcoma cells, and BCL2 inhibited the si-PVT1#1-induced apoptosis of U2OS cells.

Long non-coding RNA PVT1 promotes osteosarcoma development by acting as a molecular sponge to regulate miR-195

PVT1 directly interacts with EZH2 and the complex anchors in the promoter region of miR-195.

LncRNA PVT1 epigenetically silences miR-195 and modulates EMT and chemoresistance in cervical cancer cells

Fatty acid biosynthesis；Metabolic pathways； Insulin signaling pathway

Moreover, silencing PVT1 by siRNA inhibited BCL2, CCND1, and FASN protein expression via miR-195 in osteosarcoma cells, and BCL2 inhibited the si-PVT1#1-induced apoptosis of U2OS cells.

Long non-coding RNA PVT1 promotes osteosarcoma development by acting as a molecular sponge to regulate miR-195