Glioma；Cell cycle；Hepatitis B；HTLV-I infection；Pathways in cancer；Pancreatic cancer；Prostate cancer；Melanoma；Bladder cancer；Non-small cell lung cancer； Chronic myeloid leukemia；Small cell lung cancer

We found that lncRNA H19 was increased in melanoma tissue, and lncRNA H19 was correlated with poor prognosis of melanoma patients. miR-106a-5p acts as a tumour suppressor in melanoma by targeting E2F3

Long non-coding RNA H19 promotes glucose metabolism and cell growth in malignant melanoma via miR-106a-5p/E2F3 axis

Glioma；Cell cycle；Hepatitis B；HTLV-I infection；Pathways in cancer；Pancreatic cancer；Prostate cancer；Melanoma；Bladder cancer；Non-small cell lung cancer； Chronic myeloid leukemia；Small cell lung cancer

Additionally, mechanistic analysis revealed that XIST up-regulated the expression of miR-34a-5p targeted gene E2F3 through acting as a competitive 'sponge' of miR-34a-5p.

Long non-coding RNA XIST exerts oncogenic functions in human nasopharyngeal carcinoma by targeting miR-34a-5p

Glioma；Cell cycle；Hepatitis B；HTLV-I infection；Pathways in cancer；Pancreatic cancer；Prostate cancer；Melanoma；Bladder cancer；Non-small cell lung cancer； Chronic myeloid leukemia；Small cell lung cancer

Additionally, by using bioinformatics study and RNA pull down combined with luciferase reporter assays, we demonstrated that NEAT1 functioned as a competing endogenous RNA (ceRNA) for hsa-miR-377-3p, antagonized its functions and led to the de-repression of its endogenous targets E2F3, which was a core oncogene in promoting NSCLC progression.

Long non-coding RNA NEAT1 promotes non-small cell lung cancer progression through regulation of miR-377-3p-E2F3 pathway