| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| PVT1 | miR-186 | Atg7 | ATG7；APG7-LIKE；APG7L；GSA7 | details
Regulation of autophagy
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In conclusion, PVT1 overexpression increased the expression of Atg7 and Beclin1 by targeting miR-186, which induced protective autophagy, thus promoting glioma vascular endothelial cell proliferation, migration, and angiogenesis.
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PVT1 affects growth of glioma microvascular endothelial cells by negatively regulating miR-186
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Glioma | Tumour Biol | 28351322 |
| PVT1 | miR-186 | Beclin1 | BECN1；ATG6；VPS30；beclin1 | details
Regulation of autophagy
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In conclusion, PVT1 overexpression increased the expression of Atg7 and Beclin1 by targeting miR-186, which induced protective autophagy, thus promoting glioma vascular endothelial cell proliferation, migration, and angiogenesis.
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PVT1 affects growth of glioma microvascular endothelial cells by negatively regulating miR-186
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Glioma | Tumour Biol | 28351322 |
| TUG1 | miR-186 | CPEB2 | CPEB2；CPE-BP2；CPEB-2；hCPEB-2 | details | details
Furthermore, bioinformatics analysis showed that miR-186 could directly bind to TUG1, suggesting TUG1 might worked as a ceRNA to sponge miR-186. Extensively, our study also showed that CPEB2 was the direct target of miR-186 in colorectal cancer cells. Taken together, our study suggests that lncRNA TUG1 mediates MTX resistance in colorectal cancer via miR-186/CPEB2 axis.
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TUG1 mediates methotrexate resistance in colorectal cancer via miR-186/CPEB2 axis
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Colorectal Cancer | Biochem Biophys Res Commun | 28302487 |
| TUG1 | miR-186 | CPEB2 | CPEB2CPE-BP2；CPEB-2；hCPEB-2 | details | details
Furthermore, bioinformatics analysis showed that miR-186 could directly bind to TUG1, suggesting TUG1 might worked as a ceRNA to sponge miR-186. Extensively, our study also showed that CPEB2 was the direct target of miR-186 in colorectal cancer cells. Taken together, our study suggests that lncRNA TUG1 mediates MTX resistance in colorectal cancer via miR-186/CPEB2 axis.
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TUG1 mediates methotrexate resistance in colorectal cancer via miR-186/CPEB2 axis.
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Colorectal cancer | Biochem Biophys Res Commun | 28302487 |
| PVT1 | miR-186 | HIF-1alpha | HIF1A；HIF-1A；HIF-1alpha；HIF1；HIF1-ALPHA；MOP1；PASD8；bHLHe78 | details
HIF-1 signaling pathway；mTOR signaling pathway；Pathways in cancer；Proteoglycans in cancer；Renal cell carcinoma
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In addition, PVT1 could directly interact with miR-186 in GC cells and this interaction lead to the inhibition of downstream of HIF-1α expression.
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The long noncoding RNA PVT1 functions as a competing endogenous RNA by sponging miR-186 in gastric cancer
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Gastric Cancer | Biomed Pharmacother | 28122299 |
| PVT1 | miR-186 | Twist1 | TWIST1；ACS3；BPES2；BPES3；CRS；CRS1；CSO；SCS；TWIST；bHLHa38 | details
Proteoglycans in cancer
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We then confirmed that PVT1 acts as a sponge for miRNA-186-5p and positively regulates Twist1 by a sponge effect. Therefore, this study has revealed a novel MECHANISM for the promotion of EMT in prostate cancer by PVT1. Our findings suggest that the PVT1/miR-186/Twist1 regulatory axis may be a new therapeutic target for prostate cancer.
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Long noncoding RNA PVT1 promotes EMT via mediating microRNA-186 targeting of Twist1 in prostate cancer
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Prostate cancer | Gene | 29452232 |