Hippo signaling pathway；MAPK signaling pathway；Cytokine-cytokine receptor interaction；Cell cycle；Endocytosis；TGF-beta signaling pathway；Renal cell carcinoma；Hypertrophic cardiomyopathy (HCM)；Chronic myeloid leukemia；Toxoplasmosis；Pathways in cancer；Osteoclast differentiation；HTLV-I infection；Proteoglycans in cancer；Intestinal immune network for IgA production；Rheumatoid arthritis；Dilated cardiomyopathy；Hepatitis B；Pancreatic cancer；Leishmaniasis；Tuberculosis；Chagas disease (American trypanosomiasis)；Colorectal cancer； Malaria

Subsequently, functional experiments revealed circRNA_010567 silencing could up-regulate miR-141 and down-regulate TGF-β1 expression, and suppress fibrosis-associated protein resection in CFs, including Col I, Col III and α-SMA. Results demonstrate the circRNA_010567/miR-141/TGF-β1 axis plays an important regulatory role in the diabetic mice myocardial fibrosis model.

A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-β1.