Cholinergic synapse；HIF-1 signaling pathway；Chemokine signaling pathway；MAPK signaling pathway；Small cell lung cancer；Toll-like receptor signaling pathway；Fc epsilon RI signaling pathway；T cell receptor signaling pathway；ErbB signaling pathway；Carbohydrate digestion and absorption；Chagas disease (American trypanosomiasis)；mTOR signaling pathway；PI3K-Akt signaling pathway；Hepatitis B；HTLV-I infection；Pathways in cancer；Toxoplasmosis；Colorectal cancer；Endometrial cancer；Jak-STAT signaling pathway；Neurotrophin signaling pathway；Influenza A；Proteoglycans in cancer； Measles；Dopaminergic synapse；Tuberculosis；Prostate cancer；Non-small cell lung cancer；Apoptosis；Progesterone-mediated oocyte maturation；Melanoma；Chronic myeloid leukemia； B cell receptor signaling pathway； Insulin signaling pathway；Renal cell carcinoma；Estrogen signaling pathway；VEGF signaling pathway；Osteoclast differentiation；Glioma；Epstein-Barr virus infection； Focal adhesion；Tight junction；Hepatitis C；Fc gamma R-mediated phagocytosis；Pancreatic cancer；Acute myeloid leukemia；Adipocytokine signaling pathway

Collectively, our findings established Linc00152 as a candidate prognostic indicator of outcome and drug responsiveness in colon cancer patients, and the involvement of competing endogenous RNAs mechanism in Linc00152/miR-193a-3p/ERBB4/AKT signaling axis may provide a novel choice in the investigation of drug resistance.

Linc00153 Functions as a Competing Endogenous RNA to Confer Oxaliplatin Resistance and Holds Prognostic Values in Colon Cancer

Cholinergic synapse；HIF-1 signaling pathway；Chemokine signaling pathway；MAPK signaling pathway；Small cell lung cancer；Toll-like receptor signaling pathway；Fc epsilon RI signaling pathway；T cell receptor signaling pathway；ErbB signaling pathway；Carbohydrate digestion and absorption；Chagas disease (American trypanosomiasis)；mTOR signaling pathway；PI3K-Akt signaling pathway；Hepatitis B；HTLV-I infection；Pathways in cancer；Toxoplasmosis；Colorectal cancer；Endometrial cancer；Jak-STAT signaling pathway；Neurotrophin signaling pathway；Influenza A；Proteoglycans in cancer； Measles；Dopaminergic synapse；Tuberculosis；Prostate cancer；Non-small cell lung cancer；Apoptosis；Progesterone-mediated oocyte maturation；Melanoma；Chronic myeloid leukemia； B cell receptor signaling pathway； Insulin signaling pathway；Renal cell carcinoma；Estrogen signaling pathway；VEGF signaling pathway；Osteoclast differentiation；Glioma；Epstein-Barr virus infection； Focal adhesion；Tight junction；Hepatitis C；Fc gamma R-mediated phagocytosis；Pancreatic cancer；Acute myeloid leukemia；Adipocytokine signaling pathway

MALAT1 silencing significantly downregulated the expression of the miR-22-3p target gene CXCR2 via reversing the effect of the miR-22-3p, resulting in the aggravation of Oxidized low-density lipoprotein (ox-LDL)-induced endothelial injury； this process was associated with the AKT pathway.

The lncRNA MALAT1 protects the endothelium against ox-LDL-induced dysfunction via upregulating the expression of the miR-22-3p target genes CXCR2 and AKT

Dopaminergic synapse；ErbB signaling pathway；MAPK signaling pathway；Prostate cancer；Pathways in cancer；Melanoma；Pancreatic cancer；Chemokine signaling pathway；Fc epsilon RI signaling pathway；HIF-1 signaling pathway；Progesterone-mediated oocyte maturation；Colorectal cancer；HTLV-I infection；mTOR signaling pathway；Toll-like receptor signaling pathway；Toxoplasmosis；Epstein-Barr virus infection；Proteoglycans in cancer；Influenza A；Cholinergic synapse；Fc gamma R-mediated phagocytosis；Neurotrophin signaling pathway；Jak-STAT signaling pathway；T cell receptor signaling pathway；Acute myeloid leukemia；Glioma；Small cell lung cancer；Non-small cell lung cancer；PI3K-Akt signaling pathway； Apoptosis；VEGF signaling pathway；Hepatitis C；Carbohydrate digestion and absorption；Chagas disease (American trypanosomiasis)；Measles；Adipocytokine signaling pathway；Tuberculosis； Osteoclast differentiation；B cell receptor signaling pathway；Hepatitis B；Focal adhesion；Estrogen signaling pathway；Insulin signaling pathway；Tight junction；Endometrial cancer；Chronic myeloid leukemia；Renal cell carcinoma

In addition, overexpression of H19 in GBC-SD cells downregulated miR-194-5p and markedly increased AKT2 expression, and miR-194-5p mimic reversed these effects.

Long noncoding RNA H19 contributes to gallbladder cancer cell proliferation by modulated miR-194-5p targeting AKT2