LncCeRBase

Welcome to the LncCeRBase DataBase!
LncRNA MiRNA Gene Gene name Pathway Name Description Title Disease/Tissue Journal PubMed ID
PVT1 miR-200b EZH2 EZH2;ENX-1;ENX1;EZH1;EZH2b;KMT6;KMT6A;WVS;WVS2 details
details
Mechanistically, we verified that PVT1 binds to EZH2, recruits EZH2 to the miR-200b promoter, increases histone H3K27 trimethylation level on the miR-200b promoter, and inhibits miR-200b expression.
details
Long noncoding RNA PVT1 promotes cervical cancer progression through epigenetically silencing miR-200b
Cervical Cancer APMIS 27272214
lnc-ATB miR-200b Kindlin-2 FERMT2;KIND2;MIG2;PLEKHC1;UNC112;UNC112B;mig-2 details
details
Mechanistic investigation indicated that lnc-ATB exerted oncogenic activities via regulating Kindlin-2, as the anti-migration role of lnc-ATB silence was attenuated by ectopic expression of Kindlin-2. Further analysis showed that lnc-ATB functions as a molecular sponge for miR-200b and Kindlin-2.
details
Long non-coding RNA ATB promotes malignancy of esophageal squamous cell carcinoma by regulating miR-200b/Kindlin-2 axis.
Esophageal squamous cell carcinoma Cell Death Dis 28640252
H19 miR-200b MET MET;AUTS9;DFNB97;HGFR;RCCP2;c-Met details
Cytokine-cytokine receptor interaction;Endocytosis;PI3K-Akt signaling pathway;Axon guidance;Focal adhesion;Adherens junction;Bacterial invasion of epithelial cells;Proteoglycans in cancer;Renal cell carcinoma;Melanoma;Epithelial cell signaling in Helicobacter pylori infection;Malaria;Pathways in cancer;Transcriptional misregulation in cancer
details
We isolated cells from the primary mammary tumor, the circulation, and metastatic lesions in the lung in TA2 mice and found that the long noncoding RNA (lncRNA) H19 mediated EMT and MET by differentially acting as a sponge for the microRNAs miR-200b/c and let-7b.
details
The lncRNA H19 mediates breast cancer cell plasticity during EMT and MET plasticity by differentially sponging miR-200b/c and let-7b.
Breast cancer Sci Signal 28611183
H19 miR-200b ZEB1 ZEB1;AREB6;BZP;DELTAEF1;FECD6;NIL2A;PPCD3;TCF8;ZFHEP;ZFHX1A details
Transcriptional misregulation in cancer
details
Furthermore, we showed that H19 promotes metastasis through upregulation of ZEB1 and ZEB2 by competitively binding the miR-200 family.
details
H19 Functions as a ceRNA in Promoting Metastasis Through Decreasing miR-200s Activity in Osteosarcoma
Osteosarcoma DNA Cell Biol 27008415
H19 miR-200b ZEB2 ZEB2;HSPC082;SIP-1;SIP1;SMADIP1;ZFHX1B details
details
Furthermore, we showed that H19 promotes metastasis through upregulation of ZEB1 and ZEB2 by competitively binding the miR-200 family.
details
H19 Functions as a ceRNA in Promoting Metastasis Through Decreasing miR-200s Activity in Osteosarcoma
Osteosarcoma DNA Cell Biol 27008415
MALAT1 miR-200b ZEB2 ZEB2;HSPC082;SIP-1;SIP1;SMADIP1;ZFHX1B details
details
We further demonstrated MALAT1 promote KIRC proliferation and metastasis through sponging miR-200s in vitro and in vivo. In addition, miR-200c can partly reverse the MALAT1's stimulation on proliferation and metastasis in KIRC. In summary we unveil a branch of the MALAT1/miR-200s/ZEB2 pathway that regulates the progression of KIRC.
details
LncRNA MALAT1 functions as a competing endogenous RNA to regulate ZEB2 expression by sponging miR-200s in clear cell kidney carcinoma
Kidney Carcinoma Oncotarget 26461224