LncCeRBase

Welcome to the LncCeRBase DataBase!
LncRNA MiRNA Gene Gene name Pathway Name Description Title Disease/Tissue Journal PubMed ID
SNHG6-003 miR-26b AKT1 AKT1;AKT;CWS6;PKB;PKB-ALPHA;PRKBA;RAC;RAC-ALPHA details
Apoptosis;MAPK signaling pathway;Acute myeloid leukemia;ErbB signaling pathway;Chemokine signaling pathway;Fc gamma R-mediated phagocytosis;Insulin signaling pathway;Pathways in cancer;Melanoma;Dopaminergic synapse;Colorectal cancer;Estrogen signaling pathway;HTLV-I infection;Toll-like receptor signaling pathway;Glioma;Adipocytokine signaling pathway;HIF-1 signaling pathway;Jak-STAT signaling pathway;Proteoglycans in cancer;Toxoplasmosis;B cell receptor signaling pathway;Small cell lung cancer;Progesterone-mediated oocyte maturation;Non-small cell lung cancer;Measles;Fc epsilon RI signaling pathway;mTOR signaling pathway;PI3K-Akt signaling pathway;Chagas disease (American trypanosomiasis);Hepatitis C;VEGF signaling pathway;Prostate cancer;Renal cell carcinoma;Tuberculosis;Influenza A;T cell receptor signaling pathway;Osteoclast differentiation;Carbohydrate digestion and absorption; Endometrial cancer;Pancreatic cancer;Chronic myeloid leukemia;Cholinergic synapse;Hepatitis B;Focal adhesion;Epstein-Barr virus infection; Neurotrophin signaling pathway;Tight junction
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Moreover, SNHG6-003 functioned as a competitive endogenous RNA (ceRNA), effectively becoming sponge for miR-26a/b and thereby modulating the expression of transforming growth factor-β-activated kinase 1 (TAK1).
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The long non-coding RNA, SNHG6-003, functions as a competing endogenous RNA to promote the progression of hepatocellular carcinoma
Hepatocellular Carcinoma ONCOGENE 27530352
Malat1 miR-26b ULK2 ULK2;ATG1B;Unc51.2 details
Regulation of autophagy;mTOR signaling pathway
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We further explored the molecular mechanisms by which Malat1 exerted regulatory effects, and found that Malat1 served as an endogenous sponge to downregulate miR-26b expression by binding directly to miR-26b. Furthermore, Malat1 overturned the inhibitory effect of miR-26b on BMEC autophagy and survival, which involved in promoting the expression of miR-26b target ULK2.
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Long noncoding RNA Malat1 is a potent autophagy inducer protecting brain microvascular endothelial cells against oxygen-glucose deprivation/reoxygenation-induced injury by sponging miR-26b and upregulating ULK2 expression.
Brain microvascular endothelial cell Neuroscience 28433650