| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| circ-TTBK2 | miR-217 | HNF1beta | HNF1B；FJHN；HNF-1-beta；HNF-1B；HNF1beta；HNF2；HPC11；LF-B3；LFB3；MODY5；TCF-2；TCF2；VHNF1 | details
Maturity onset diabetes of the young
|
details
We also found that circ-TTBK2, but not linear TTBK2, acted as miR-217 sponge in a sequence-specific manner. In addition, upregulated circ-TTBK2 decreased miR-217 expression and there was a reciprocal negative feedback between them in an Argonaute2-dependent manner. Moreover, reintroduction of miR-217 significantly reversed circ-TTBK2-mediated promotion of glioma progression. HNF1β was a direct target of miR-217, and played oncogenic role in glioma cells.
|
details
TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1β/Derlin-1 pathway
|
Glioma | J Hematol Oncol | 28219405 |