Renal cell carcinoma；Cytokine-cytokine receptor interaction；Rheumatoid arthritis；HIF-1 signaling pathway；mTOR signaling pathway；PI3K-Akt signaling pathway；VEGF signaling pathway；Focal adhesion；Pathways in cancer；Proteoglycans in cancer；Pancreatic cancer；Bladder cancer

For instance, through its miRNA response elements (MREs) to compete for miR-106a-5p, lncRNA-FER1L4 regulates the expression of PTEN, RB1, RUNX1, VEGFA, CDKN1A, E2F1, HIPK3, IL-10, and PAK7.

Long noncoding RNA associated-competing endogenous RNAs in gastric cancer PTENP1 Functions as a Competing Endogenous RNA (ceRNA) to Regulate PTEN Expression by Sponging miR-499-5p.

HIF-1 signaling pathway；Cytokine-cytokine receptor interaction；mTOR signaling pathway；PI3K-Akt signaling pathway； VEGF signaling pathway；Focal adhesion； Pathways in cancer；Proteoglycans in cancer；Renal cell carcinoma；Pancreatic cancer；Bladder cancer；Rheumatoid arthritis

Furthermore, HOTAIR was shown to directly bind to and inhibit miR-126 expression and then to promote VEGFA and PIK3R2 expression and activate the PI3K/AKT/MRP1 pathway.

LncRNA HOTAIR promotes cisplatin resistance in gastric cancer by targeting miR-126 to activate the PI3K/AKT/MRP1 genes

HIF-1 signaling pathway；Cytokine-cytokine receptor interaction；mTOR signaling pathway；PI3K-Akt signaling pathway； VEGF signaling pathway；Focal adhesion； Pathways in cancer；Proteoglycans in cancer；Renal cell carcinoma；Pancreatic cancer；Bladder cancer；Rheumatoid arthritis

Moreover, knockdown of TUG1 reduced the expression of vascular endothelial growth factor A (VEGFA), which was defined as a functional downstream target of miR-299.

Long non-coding RNA taurine upregulated 1 enhances tumor-induced angiogenesis through inhibiting microRNA-299 in human glioblastoma

HIF-1 signaling pathway；Cytokine-cytokine receptor interaction；mTOR signaling pathway；PI3K-Akt signaling pathway； VEGF signaling pathway；Focal adhesion； Pathways in cancer；Proteoglycans in cancer；Renal cell carcinoma；Pancreatic cancer；Bladder cancer；Rheumatoid arthritis

TUG1 knockdown inhibits tumor growth and angiogenesis in vivo, and decreases hepatoblastoma cell viability, proliferation, migration, and invasion in vitro. TUG1, miR-34a-5p, and VEGFA constitutes to a regulatory network, and participates in regulating hepatoblastoma cell function, tumor progression, and tumor angiogenesis.

Targeting long non-coding RNA-TUG1 inhibits tumor growth and angiogenesis in hepatoblastoma

mTOR signaling pathway；Cytokine-cytokine receptor interaction；HIF-1 signaling pathway；PI3K-Akt signaling pathway；VEGF signaling pathway；Focal adhesion；Pathways in cancer；Proteoglycans in cancer；Renal cell carcinoma；Rheumatoid arthritis；Pancreatic cancer；Bladder cancer

Furthermore, HOTAIR was shown to directly bind to and inhibit miR-126 expression and then to promote VEGFA and PIK3R2 expression and activate the PI3K/AKT/MRP1 pathway.

LncRNA HOTAIR promotes cisplatin resistance in gastric cancer by targeting miR-126 to activate the PI3K/AKT/MRP1 genes