LncCeRBase

Welcome to the LncCeRBase DataBase!
LncRNA MiRNA Gene Gene name Pathway Name Description Title Disease/Tissue Journal PubMed ID
MALAT1 miR-206 ANXA2 ANXA2;ANX2;ANX2L4;CAL1H;HEL-S-270;LIP2;LPC2;LPC2D;P36;PAP-IV details
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We also show that Malat1 functions as a competing endogenous RNA (ceRNA) for miR-206. Because miR-206 directly suppresses expression of ANXA2 and KRAS, which are thought to promote GBC progression, Malat1 binding of miR-206 in GBC tissue and cells has an oncogenic effect. Conversely, Malat1 knockdown inhibits proliferation and invasion by GBC cells while increasing apoptosis.
details
Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206
Gallbladder Cancer Oncotarget 27191262
RMRP miR-206 Cyclin D2 CCND2;KIAK0002;MPPH3 details
Wnt signaling pathway;Cell cycle;p53 signaling pathway;PI3K-Akt signaling pathway;Hippo signaling pathway; Focal adhesion;Jak-STAT signaling pathway;Measles;HTLV-I infection;Transcriptional misregulation in cancer;Viral carcinogenesis
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Acting as a miR-206 sponge, RMRP modulated cell cycle by regulating Cyclin D2 expression.
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LncRNA-RMRP promotes carcinogenesis by acting as a miR-206 sponge and is used as a novel biomarker for gastric cancer
Gastric Cancer Oncotarget 27192121
RMRP miR-206 FMNL2 FMNL2;FHOD2 details
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In addition, overexpression of RMRP inhibited the miR-206 expression in the H1299 cell and increased the KRAS, FMNL2 and SOX9 expression, which were the target genes of miR-206. Re-expression of miR-206 reversed the RMRP-induced the H1299 cell proliferation and migration.
details
LncRNA-RMRP Acts as an Oncogene in Lung Cancer
Lung Cancer PLoS One 27906963
MALAT1 miR-206 KRAS KRAS;C-K-RAS;CFC2;K-RAS2A;K-RAS2B;K-RAS4A;K-RAS4B;KI-RAS;KRAS1;KRAS2;NS;NS3;RASK2 details
Natural killer cell mediated cytotoxicity;MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;PI3K-Akt signaling pathway;Insulin signaling pathway;Hepatitis C;Long-term potentiation;Progesterone-mediated oocyte maturation;Dorso-ventral axis formation;Axon guidance;Endometrial cancer;Regulation of actin cytoskeleton;VEGF signaling pathway;Long-term depression;Estrogen signaling pathway;Cholinergic synapse;Melanogenesis;Hepatitis B;Viral carcinogenesis;Tight junction;Neurotrophin signaling pathway;GnRH signaling pathway;Gap junction;Glioma;T cell receptor signaling pathway; Alcoholism;Prostate cancer;Serotonergic synapse;Bladder cancer;Non-small cell lung cancer;Chronic myeloid leukemia;HTLV-I infection;B cell receptor signaling pathway;Pathways in cancer;Aldosterone-regulated sodium reabsorption;Colorectal cancer;Melanoma;Acute myeloid leukemia;Proteoglycans in cancer;Pancreatic cancer;Renal cell carcinoma;Thyroid cancer;Fc epsilon RI signaling pathway
details
We also show that Malat1 functions as a competing endogenous RNA (ceRNA) for miR-206. Because miR-206 directly suppresses expression of ANXA2 and KRAS, which are thought to promote GBC progression, Malat1 binding of miR-206 in GBC tissue and cells has an oncogenic effect. Conversely, Malat1 knockdown inhibits proliferation and invasion by GBC cells while increasing apoptosis.
details
Long non-coding RNA Malat1 promotes gallbladder cancer development by acting as a molecular sponge to regulate miR-206
Gallbladder Cancer Oncotarget 27191262
RMRP miR-206 KRAS KRAS;C-K-RAS;CFC2;K-RAS2A;K-RAS2B;K-RAS4A;K-RAS4B;KI-RAS;KRAS1;KRAS2;NS;NS3;RASK2 details
Natural killer cell mediated cytotoxicity;MAPK signaling pathway;ErbB signaling pathway;Chemokine signaling pathway;PI3K-Akt signaling pathway;Insulin signaling pathway;Hepatitis C;Long-term potentiation;Progesterone-mediated oocyte maturation;Dorso-ventral axis formation;Axon guidance;Endometrial cancer;Regulation of actin cytoskeleton;VEGF signaling pathway;Long-term depression;Estrogen signaling pathway;Cholinergic synapse;Melanogenesis;Hepatitis B;Viral carcinogenesis;Tight junction;Neurotrophin signaling pathway;GnRH signaling pathway;Gap junction;Glioma;T cell receptor signaling pathway; Alcoholism;Prostate cancer;Serotonergic synapse;Bladder cancer;Non-small cell lung cancer;Chronic myeloid leukemia;HTLV-I infection;B cell receptor signaling pathway;Pathways in cancer;Aldosterone-regulated sodium reabsorption;Colorectal cancer;Melanoma;Acute myeloid leukemia;Proteoglycans in cancer;Pancreatic cancer;Renal cell carcinoma;Thyroid cancer;Fc epsilon RI signaling pathway
details
In addition, overexpression of RMRP inhibited the miR-206 expression in the H1299 cell and increased the KRAS, FMNL2 and SOX9 expression, which were the target genes of miR-206. Re-expression of miR-206 reversed the RMRP-induced the H1299 cell proliferation and migration.
details
LncRNA-RMRP Acts as an Oncogene in Lung Cancer
Lung Cancer PLoS One 27906963
RMRP miR-206 SOX9 SOX9;CMD1;CMPD1;SRA1;SRXX2;SRXY10 details
details
In addition, overexpression of RMRP inhibited the miR-206 expression in the H1299 cell and increased the KRAS, FMNL2 and SOX9 expression, which were the target genes of miR-206. Re-expression of miR-206 reversed the RMRP-induced the H1299 cell proliferation and migration.
details
LncRNA-RMRP Acts as an Oncogene in Lung Cancer
Lung Cancer PLoS One 27906963