Cell cycle；p53 signaling pathway；Endometrial cancer；Melanoma；Thyroid cancer；PI3K-Akt signaling pathway；Pancreatic cancer；Wnt signaling pathway；Hippo signaling pathway；Prostate cancer；Acute myeloid leukemia；Focal adhesion；Viral myocarditis；Viral carcinogenesis；Colorectal cancer；Jak-STAT signaling pathway；Hepatitis B；Measles；Proteoglycans in cancer；Bladder cancer；Non-small cell lung cancer；HTLV-I infection；Small cell lung cancer；Pathways in cancer；Glioma；Chronic myeloid leukemia

Furthermore, HOTAIR overturned the effect of miR-1 on the proliferation and cell cycle profile in ESCC cells, which involved the derepression of cyclin D1 (CCND1) expression, a target of miR-1.

Long Noncoding RNA HOTAIR Controls Cell Cycle by Functioning as a Competing Endogenous RNA in Esophageal Squamous Cell Carcinoma

Cell cycle；p53 signaling pathway；Endometrial cancer；Melanoma；Thyroid cancer；PI3K-Akt signaling pathway；Pancreatic cancer；Wnt signaling pathway；Hippo signaling pathway；Prostate cancer；Acute myeloid leukemia；Focal adhesion；Viral myocarditis；Viral carcinogenesis；Colorectal cancer；Jak-STAT signaling pathway；Hepatitis B；Measles；Proteoglycans in cancer；Bladder cancer；Non-small cell lung cancer；HTLV-I infection；Small cell lung cancer；Pathways in cancer；Glioma；Chronic myeloid leukemia

Moreover, silencing PVT1 by siRNA inhibited BCL2, CCND1, and FASN protein expression via miR-195 in osteosarcoma cells, and BCL2 inhibited the si-PVT1#1-induced apoptosis of U2OS cells.

Long non-coding RNA PVT1 promotes osteosarcoma development by acting as a molecular sponge to regulate miR-195

The results showed that hsa_circ_0013958 promoted cell proliferation and invasion and inhibited cell apoptosis in LAC. Moreover, hsa_circ_0013958 was identified as a sponge of miR-134, and thus it up-regulated oncogenic cyclin D1, which plays a pivotal role in the development of non-small cell lung cancer.

hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma.

In addition, mechanistic analysis demonstrated that EWSAT1 up-regulated the expression of miR-326/330-5p clusters targeted gene cyclin D1 through acting as a competitive 'sponge' of miR-326/330-5p clusters.

Long non-coding RNA EWSAT1 promotes human nasopharyngeal carcinoma cell growth in vitro by targeting miR-326/-330-5p

In addition, mechanistic analysis demonstrated that EWSAT1 up-regulated the expression of miR-326/330-5p clusters targeted gene cyclin D1 through acting as a competitive 'sponge' of miR-326/330-5p clusters.

Long non-coding RNA EWSAT1 promotes human nasopharyngeal carcinoma cell growth in vitro by targeting miR-326/-330-5p