Toll-like receptor signaling pathway；Apoptosis；NF-kappa B signaling pathway；Salmonella infection；Pertussis；Legionellosis；Leishmaniasis；Chagas disease (American trypanosomiasis)；Measles；African trypanosomiasis；Tuberculosis；Influenza A；Herpes simplex infection； Malaria；Hepatitis B；Toxoplasmosis

Moreover, the up-regulated lncRNA cardiac hypertrophy-related factor (CHRF) reversed the inhibitory effect of miR-489 on MyD88 and Smad3 and then triggered the inflammation and fibrotic signaling pathways.

miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF

Endocytosis；Cell cycle；Wnt signaling pathway；TGF-beta signaling pathway；Hippo signaling pathway；Chronic myeloid leukemia；Adherens junction；Chagas disease (American trypanosomiasis)； HTLV-I infection；Pathways in cancer；Colorectal cancer；Pancreatic cancer

Moreover, the up-regulated lncRNA cardiac hypertrophy-related factor (CHRF) reversed the inhibitory effect of miR-489 on MyD88 and Smad3 and then triggered the inflammation and fibrotic signaling pathways.

miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF

Furthermore, we identified MHENCR as a competitively endogenous RNA, which specifically bound to miR-425 and miR-489, upregulated their target genes IGF1 and SPIN1 expression, and further activated PI3K-Akt pathway.

Long noncoding RNA MHENCR promotes melanoma progression via regulating miR-425/489-mediated PI3K-Akt pathway