Chemokine signaling pathway；MAPK signaling pathway；Endocytosis；Axon guidance；Epithelial cell signaling in Helicobacter pylori infection；Viral carcinogenesis；Neurotrophin signaling pathway；Bacterial invasion of epithelial cells；Renal cell carcinoma；Shigellosis；Salmonella infection；Pancreatic cancer；VEGF signaling pathway；Focal adhesion；Pathways in cancer；Pathogenic Escherichia coli infection；Adherens junction；Tight junction；GnRH signaling pathway；Regulation of actin cytoskeleton；T cell receptor signaling pathway；Fc gamma R-mediated phagocytosis；Leukocyte transendothelial migration；Proteoglycans in cancer

In this study we identified long non-coding RNA (lncRNA) MALAT1 can function as a ceRNA of cell division cycle 42 (cdc42) 3'UTR in inducing migration and invasion of breast cancer cells via miR-1. We found that miR-1 bound both MALAT1 and cdc42 3'UTR directly.

MALAT1 induced migration and invasion of human breast cancer cells by competitively binding miR-1 with cdc42

Chemokine signaling pathway；MAPK signaling pathway；Endocytosis；Axon guidance；Epithelial cell signaling in Helicobacter pylori infection；Viral carcinogenesis；Neurotrophin signaling pathway；Bacterial invasion of epithelial cells；Renal cell carcinoma；Shigellosis；Salmonella infection；Pancreatic cancer；VEGF signaling pathway；Focal adhesion；Pathways in cancer；Pathogenic Escherichia coli infection；Adherens junction；Tight junction；GnRH signaling pathway；Regulation of actin cytoskeleton；T cell receptor signaling pathway；Fc gamma R-mediated phagocytosis；Leukocyte transendothelial migration；Proteoglycans in cancer

Among them, Ribonuclease P RNA component H1 (Rpph1) is upregulated in the cortex of APPswe/PS1ΔE9 mice compared to wild type controls. Rpph1 binds to miR326-3p/miR-330-5p and causes the release of their downstream target Cdc42, which leads to CDC42 upregulation.

Rpph1 Upregulates CDC42 Expression and Promotes Hippocampal Neuron Dendritic Spine Formation by Competing with miR-330-5p

Chemokine signaling pathway；MAPK signaling pathway；Endocytosis；Axon guidance；Epithelial cell signaling in Helicobacter pylori infection；Viral carcinogenesis；Neurotrophin signaling pathway；Bacterial invasion of epithelial cells；Renal cell carcinoma；Shigellosis；Salmonella infection；Pancreatic cancer；VEGF signaling pathway；Focal adhesion；Pathways in cancer；Pathogenic Escherichia coli infection；Adherens junction；Tight junction；GnRH signaling pathway；Regulation of actin cytoskeleton；T cell receptor signaling pathway；Fc gamma R-mediated phagocytosis；Leukocyte transendothelial migration；Proteoglycans in cancer

Among them, Ribonuclease P RNA component H1 (Rpph1) is upregulated in the cortex of APPswe/PS1ΔE9 mice compared to wild type controls. Rpph1 binds to miR326-3p/miR-330-5p and causes the release of their downstream target Cdc42, which leads to CDC42 upregulation.

Rpph1 Upregulates CDC42 Expression and Promotes Hippocampal Neuron Dendritic Spine Formation by Competing with miR-330-5p