Cholinergic synapse；HIF-1 signaling pathway；Chemokine signaling pathway；MAPK signaling pathway；Small cell lung cancer；Toll-like receptor signaling pathway；Fc epsilon RI signaling pathway；T cell receptor signaling pathway；ErbB signaling pathway；Carbohydrate digestion and absorption；Chagas disease (American trypanosomiasis)；mTOR signaling pathway；PI3K-Akt signaling pathway；Hepatitis B；HTLV-I infection；Pathways in cancer；Toxoplasmosis；Colorectal cancer；Endometrial cancer；Jak-STAT signaling pathway；Neurotrophin signaling pathway；Influenza A；Proteoglycans in cancer； Measles；Dopaminergic synapse；Tuberculosis；Prostate cancer；Non-small cell lung cancer；Apoptosis；Progesterone-mediated oocyte maturation；Melanoma；Chronic myeloid leukemia； B cell receptor signaling pathway； Insulin signaling pathway；Renal cell carcinoma；Estrogen signaling pathway；VEGF signaling pathway；Osteoclast differentiation；Glioma；Epstein-Barr virus infection； Focal adhesion；Tight junction；Hepatitis C；Fc gamma R-mediated phagocytosis；Pancreatic cancer；Acute myeloid leukemia；Adipocytokine signaling pathway

In particular, our results suggested that lncRNA-XIST may act as a competitive endogenous RNA, effectively becoming a sink for miR-494, leading to derepression of its target gene, phosphatase and tensin homolog deleted on chromosome ten (PTEN). In addition, an inverse relationship between lncRNA-XIST and miR-494 was observed in spinal cord tissues of SCI rats. Further study demonstrated that antagomiR-494 could reverse the protective effects of lncRNA-XIST knockdown on SCI rats through blocking the PTEN/PI3K/AKT signaling pathway.

Long Coding RNA XIST Contributes to Neuronal Apoptosis through the Downregulation of AKT Phosphorylation and Is Negatively Regulated by miR-494 in Rat Spinal Cord Injury

p53 signaling pathway；Inositol phosphate metabolism；Prostate cancer；Phosphatidylinositol signaling system；mTOR signaling pathway；PI3K-Akt signaling pathway；Focal adhesion；Tight junction；Hepatitis B；Pathways in cancer；Melanoma；Endometrial cancer；Glioma；Small cell lung cancer

In particular, our results suggested that lncRNA-XIST may act as a competitive endogenous RNA, effectively becoming a sink for miR-494, leading to derepression of its target gene, phosphatase and tensin homolog deleted on chromosome ten (PTEN). In addition, an inverse relationship between lncRNA-XIST and miR-494 was observed in spinal cord tissues of SCI rats. Further study demonstrated that antagomiR-494 could reverse the protective effects of lncRNA-XIST knockdown on SCI rats through blocking the PTEN/PI3K/AKT signaling pathway.

Long Coding RNA XIST Contributes to Neuronal Apoptosis through the Downregulation of AKT Phosphorylation and Is Negatively Regulated by miR-494 in Rat Spinal Cord Injury

p53 signaling pathway；Inositol phosphate metabolism；Prostate cancer；Phosphatidylinositol signaling system；mTOR signaling pathway；PI3K-Akt signaling pathway；Focal adhesion；Tight junction；Hepatitis B；Pathways in cancer；Melanoma；Endometrial cancer；Glioma；Small cell lung cancer

In particular, our results suggested that lncRNA-XIST may act as a competitive endogenous RNA, effectively becoming a sink for miR-494, leading to derepression of its target gene, phosphatase and tensin homolog deleted on chromosome ten (PTEN).

Long Coding RNA XIST Contributes to Neuronal Apoptosis through the Downregulation of AKT Phosphorylation and Is Negatively Regulated by miR-494 in Rat Spinal Cord Injury