Axon guidance；Phagosome；PI3K-Akt signaling pathway；Focal adhesion；ECM-receptor interaction；Toxoplasmosis；Cell adhesion molecules (CAMs)；Leukocyte transendothelial migration；Regulation of actin cytoskeleton；Hypertrophic cardiomyopathy (HCM)；Dilated cardiomyopathy；Proteoglycans in cancer；Arrhythmogenic right ventricular cardiomyopathy (ARVC)；Bacterial invasion of epithelial cells；Leishmaniasis；Pathogenic Escherichia coli infection；Pertussis；Pathways in cancer；Small cell lung cancer；Shigellosis

We further found that the expression and function of miR-183 were suppressed by MALAT1. Integrin β1 (ITGB1) was then speculated and confirmed as a direct target of miR-183. We also illustrated that MALAT1 may function as a sponge competitive endogenous RNA (ceRNA) for miR-183, and thus regulate the molecular expression of ITGB1.

Deregulation of miR-183 promotes melanoma development via lncRNA MALAT1 regulation and ITGB1 signal activation