| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| CHRF | miR-489 | Smad3 | SMAD3；HSPC193；HsT17436；JV15-2；LDS1C；LDS3；MADH3 | details
Endocytosis；Cell cycle；Wnt signaling pathway；TGF-beta signaling pathway；Hippo signaling pathway；Chronic myeloid leukemia；Adherens junction；Chagas disease (American trypanosomiasis)； HTLV-I infection；Pathways in cancer；Colorectal cancer；Pancreatic cancer
|
details
Moreover, the up-regulated lncRNA cardiac hypertrophy-related factor (CHRF) reversed the inhibitory effect of miR-489 on MyD88 and Smad3 and then triggered the inflammation and fibrotic signaling pathways.
|
details
miR-489 inhibits silica-induced pulmonary fibrosis by targeting MyD88 and Smad3 and is negatively regulated by lncRNA CHRF
|
Silicosis | Sci Rep | 27506999 |