| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| linc00673 | miR-150-5p | ZEB1 | ZEB1；AREB6；BZP；DELTAEF1；FECD6；NIL2A；PPCD3；TCF8；ZFHEP；ZFHX1A | details
Transcriptional misregulation in cancer
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Furthermore, we proved that miR-150-5p could directly target linc00673 through luciferase assay, so linc00673 could sponge miR-150-5p and modulate the expression of a key EMT regulator ZEB1 indirectly. In addition, miR-150-5p inhibition abrogated linc00673 silence mediated proliferation, migration, invasion and EMT suppressing effect. Moreover, the inhibition of linc00673 significantly attenuated the tumorigenesis ability of A549 cells in vivo.
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Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p.
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Non-small cell lung cancer | Mol Cancer | 28697764 |