LncCeRBase

Welcome to the LncCeRBase DataBase!
LncRNA MiRNA Gene Gene name Pathway Name Description Title Disease/Tissue Journal PubMed ID
PVT1 miR-497 HK2 HK2;HKII;HXK2 details
Starch and sucrose metabolism;Glycolysis / Gluconeogenesis;Fructose and mannose metabolism;Galactose metabolism;Amino sugar and nucleotide sugar metabolism;Butirosin and neomycin biosynthesis;Metabolic pathways;HIF-1 signaling pathway;Insulin signaling pathway;Type II diabetes mellitus ;Carbohydrate digestion and absorption
details
Functionally, knockdown of PVT1 exerted tumor-suppressive effect by suppressing cell proliferation, cell cycle progression, and invasion in vitro, whereas miR-497 inhibitor partially abolished the inhibition effect of si-PVT1. Overexpression of HK2 attenuated the miR-497 induced inhibition of cell growth and motility. Taken together, these findings suggested that PVT1 contributes to OS cell glucose metabolism, cell proliferation, and motility through the miR-497/HK2 pathway, and revealed a novel relation between lncRNA and the alteration of glycolysis in OS cells.
details
Long non-coding RNA PVT1 promotes glycolysis and tumor progression by regulating miR-497/HK2 axis in osteosarcoma.
Osteosarcoma Biochem Biophys Res Commun 28602700