Starch and sucrose metabolism；Glycolysis / Gluconeogenesis；Fructose and mannose metabolism；Galactose metabolism；Amino sugar and nucleotide sugar metabolism；Butirosin and neomycin biosynthesis；Metabolic pathways；HIF-1 signaling pathway；Insulin signaling pathway；Type II diabetes mellitus ；Carbohydrate digestion and absorption

Functionally, knockdown of PVT1 exerted tumor-suppressive effect by suppressing cell proliferation, cell cycle progression, and invasion in vitro, whereas miR-497 inhibitor partially abolished the inhibition effect of si-PVT1. Overexpression of HK2 attenuated the miR-497 induced inhibition of cell growth and motility. Taken together, these findings suggested that PVT1 contributes to OS cell glucose metabolism, cell proliferation, and motility through the miR-497/HK2 pathway, and revealed a novel relation between lncRNA and the alteration of glycolysis in OS cells.

Long non-coding RNA PVT1 promotes glycolysis and tumor progression by regulating miR-497/HK2 axis in osteosarcoma.