LncCeRBase

Welcome to the LncCeRBase DataBase!
LncRNA MiRNA Gene Gene name Pathway Name Description Title Disease/Tissue Journal PubMed ID
MALAT1 miR-1 slug SNAI2;SLUG;SLUGH1;SNAIL2;WS2D details
Hippo signaling pathway;Adherens junction
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In addition, our findings demonstrate a reciprocal negative control relationship between MALAT1 and miR-1: downregulation of MALAT1 increased expression of microRNA-1 (miR-1), while overexpression of miR-1 decreased MALAT1 expression. Slug was identified as a direct target of miR-1. We proposed that MALAT1 exerted its function through the miR-1/slug axis.
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Reciprocal regulation of Hsa-miR-1 and long noncoding RNA MALAT1 promotes triple-negative breast cancer development
Breast Cancer Tumour Biol 26676637
MALAT1 miR-1 slug SNAI2;SLUG;SLUGH1;SNAIL2;WS2D details
Hippo signaling pathway;Adherens junction
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Furthermore, we found that there was reciprocal repression between MALAT1 and miR-1, and slug was identified as a downstream target of miR-1.
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The role of MALAT1/miR-1/slug axis on radioresistance in nasopharyngeal carcinoma
Nasopharyngeal Carcinoma Tumour Biol 26482776
Unigene56159 miR-140-5p Slug SNAI2;SLUG;SLUGH1;SNAIL2;WS2D details
Hippo signaling pathway;Adherens junction
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Mechanistically, Unigene56159 could directly bind to miR-140-5p and effectively act as a competing endogenous RNA (ceRNA) for miR-140-5p to de-repress the expression of the target gene Slug.
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Long non-coding RNA Unigene56159 promotes epithelial-mesenchymal transition by acting as a ceRNA of miR-140-5p in hepatocellular carcinoma cells
Hepatocellular Carcinoma Cancer Lett 27597739
MALAT1 miR-204 SLUG SNAI2;SLUG;SLUGH1;SNAIL2;WS2D details
Hippo signaling pathway;Adherens junction
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In particular, MALAT1 upregulated the expression of miR-204 target gene SLUG through competitively 'spongeing' miR-204.
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LncRNA MALAT1 exerts oncogenic functions in lung adenocarcinoma by targeting miR-204
Lung Adenocarcinoma Am J Cancer Res 27294002
HOTAIR miR-148a Snail2 SNAI2;SLUG;SLUGH1;SNAIL2;WS2D details
Hippo signaling pathway;Adherens junction
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Mechanistic investigations revealed lncRNA-HOTAIR promotes the EMT by acting as a miR-148a sponge to positively regulate Snail2 expression.
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Long non-coding RNA HOTAIR functions as miRNA sponge to promote the epithelial to mesenchymal transition in esophageal cancer.
Esophageal cancer Biomed Pharmacother 28441714
UCA1 miR-203 Snail2 SNAI2;SLUG;SLUGH1;SNAIL2;WS2D details
Hippo signaling pathway;Adherens junction
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Our results identified that UCA1/miR-203/Snail2 pathway might involve in HCC progression. Inhibition of UCA1 acted as a promising therapeutic target for HCC patients.
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Long non-coding RNA UCA1 regulates the expression of Snail2 by miR-203 to promote hepatocellular carcinoma progression
Hepatocellular Carcinoma J Cancer Res Clin Oncol 28271214