LncCeRBase

Welcome to the LncCeRBase DataBase!
LncRNA MiRNA Gene Gene name Pathway Name Description Title Disease/Tissue Journal PubMed ID
ZNF609 miR-150-5p AKT3 AKT3;MPPH;MPPH2;PKB-GAMMA;PKBG;PRKBG;RAC-PK-gamma;RAC-gamma;STK-2 details
Chemokine signaling pathway;MAPK signaling pathway;Neurotrophin signaling pathway;Colorectal cancer;Insulin signaling pathway;Pancreatic cancer; Chronic myeloid leukemia;Epstein-Barr virus infection;ErbB signaling pathway;HIF-1 signaling pathway; B cell receptor signaling pathway;Tuberculosis;Prostate cancer;Fc epsilon RI signaling pathway;Renal cell carcinoma;T cell receptor signaling pathway;Progesterone-mediated oocyte maturation; Glioma;Chagas disease (American trypanosomiasis);mTOR signaling pathway; PI3K-Akt signaling pathway;Hepatitis B;Toll-like receptor signaling pathway;HTLV-I infection;Small cell lung cancer; Pathways in cancer;Apoptosis;Hepatitis C; Influenza A;Adipocytokine signaling pathway;Carbohydrate digestion and absorption;Melanoma;Toxoplasmosis;Proteoglycans in cancer;VEGF signaling pathway;Osteoclast differentiation; Jak-STAT signaling pathway;Endometrial cancer;Measles;Acute myeloid leukemia;Non-small cell lung cancer;Focal adhesion;Estrogen signaling pathway;Dopaminergic synapse;Fc gamma R-mediated phagocytosis;Cholinergic synapse; Tight junction
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In conclusion, these findings illustrated that cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p.
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Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease
Hirschsprung'S Disease Oncotarget 27903978
ZFAS1 miR-150-5p MMP14 MMP14;MMP-14;MMP-X1;MT-MMP;MT-MMP 1;MT1-MMP;MT1MMP;MTMMP1;WNCHRS details
GnRH signaling pathway
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ZFAS1 functions as an oncogene in HCC progression by binding miR-150 and abrogating its tumor-suppressive function in this setting. miR-150 repressed HCC cell invasion by inhibiting ZEB1 and the matrix metalloproteinases MMP14 and MMP16.
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Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma
Hepatocellular Carcinoma Cancer Res 26069248
ZFAS1 miR-150-5p MMP16 MMP16;C8orf57;MMP-X2;MT-MMP2;MT-MMP3;MT3-MMP details
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ZFAS1 functions as an oncogene in HCC progression by binding miR-150 and abrogating its tumor-suppressive function in this setting. miR-150 repressed HCC cell invasion by inhibiting ZEB1 and the matrix metalloproteinases MMP14 and MMP16.
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Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma
Hepatocellular Carcinoma Cancer Res 26069248
ZFAS1 miR-150-5p ZEB1 ZEB1;AREB6;BZP;DELTAEF1;FECD6;NIL2A;PPCD3;TCF8;ZFHEP;ZFHX1A details
Transcriptional misregulation in cancer
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ZFAS1 functions as an oncogene in HCC progression by binding miR-150 and abrogating its tumor-suppressive function in this setting. miR-150 repressed HCC cell invasion by inhibiting ZEB1 and the matrix metalloproteinases MMP14 and MMP16.
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Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma
Hepatocellular Carcinoma Cancer Res 26069248
linc00673 miR-150-5p ZEB1 ZEB1;AREB6;BZP;DELTAEF1;FECD6;NIL2A;PPCD3;TCF8;ZFHEP;ZFHX1A details
Transcriptional misregulation in cancer
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Furthermore, we proved that miR-150-5p could directly target linc00673 through luciferase assay, so linc00673 could sponge miR-150-5p and modulate the expression of a key EMT regulator ZEB1 indirectly. In addition, miR-150-5p inhibition abrogated linc00673 silence mediated proliferation, migration, invasion and EMT suppressing effect. Moreover, the inhibition of linc00673 significantly attenuated the tumorigenesis ability of A549 cells in vivo.
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Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p.
Non-small cell lung cancer Mol Cancer 28697764