Chemokine signaling pathway；MAPK signaling pathway；Neurotrophin signaling pathway；Colorectal cancer；Insulin signaling pathway；Pancreatic cancer； Chronic myeloid leukemia；Epstein-Barr virus infection；ErbB signaling pathway；HIF-1 signaling pathway； B cell receptor signaling pathway；Tuberculosis；Prostate cancer；Fc epsilon RI signaling pathway；Renal cell carcinoma；T cell receptor signaling pathway；Progesterone-mediated oocyte maturation； Glioma；Chagas disease (American trypanosomiasis)；mTOR signaling pathway； PI3K-Akt signaling pathway；Hepatitis B；Toll-like receptor signaling pathway；HTLV-I infection；Small cell lung cancer； Pathways in cancer；Apoptosis；Hepatitis C； Influenza A；Adipocytokine signaling pathway；Carbohydrate digestion and absorption；Melanoma；Toxoplasmosis；Proteoglycans in cancer；VEGF signaling pathway；Osteoclast differentiation； Jak-STAT signaling pathway；Endometrial cancer；Measles；Acute myeloid leukemia；Non-small cell lung cancer；Focal adhesion；Estrogen signaling pathway；Dopaminergic synapse；Fc gamma R-mediated phagocytosis；Cholinergic synapse； Tight junction

In conclusion, these findings illustrated that cir-ZNF609 took part in the onset of HSCR through the crosstalk with AKT3 by competing for shared miR-150-5p.

Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease

GnRH signaling pathway

ZFAS1 functions as an oncogene in HCC progression by binding miR-150 and abrogating its tumor-suppressive function in this setting. miR-150 repressed HCC cell invasion by inhibiting ZEB1 and the matrix metalloproteinases MMP14 and MMP16.

Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma

ZFAS1 functions as an oncogene in HCC progression by binding miR-150 and abrogating its tumor-suppressive function in this setting. miR-150 repressed HCC cell invasion by inhibiting ZEB1 and the matrix metalloproteinases MMP14 and MMP16.

Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma

Transcriptional misregulation in cancer

ZFAS1 functions as an oncogene in HCC progression by binding miR-150 and abrogating its tumor-suppressive function in this setting. miR-150 repressed HCC cell invasion by inhibiting ZEB1 and the matrix metalloproteinases MMP14 and MMP16.

Amplification of Long Noncoding RNA ZFAS1 Promotes Metastasis in Hepatocellular Carcinoma

Transcriptional misregulation in cancer

Furthermore, we proved that miR-150-5p could directly target linc00673 through luciferase assay, so linc00673 could sponge miR-150-5p and modulate the expression of a key EMT regulator ZEB1 indirectly. In addition, miR-150-5p inhibition abrogated linc00673 silence mediated proliferation, migration, invasion and EMT suppressing effect. Moreover, the inhibition of linc00673 significantly attenuated the tumorigenesis ability of A549 cells in vivo.

Long non-coding RNA linc00673 regulated non-small cell lung cancer proliferation, migration, invasion and epithelial mesenchymal transition by sponging miR-150-5p.