LncCeRBase

Welcome to the LncCeRBase DataBase!
LncRNA MiRNA Gene Gene name Pathway Name Description Title Disease/Tissue Journal PubMed ID
TCONS_00075467 miR-328 CACNA1C CACNA1C;CACH2;CACN2;CACNL1A1;CCHL1A1;CaV1.2;LQT8;TS details
Long-term potentiation;MAPK signaling pathway;Calcium signaling pathway;Type II diabetes mellitus;Arrhythmogenic right ventricular cardiomyopathy (ARVC);Cardiac muscle contraction;Vascular smooth muscle contraction;GnRH signaling pathway;Hypertrophic cardiomyopathy (HCM);Circadian entrainment;Retrograde endocannabinoid signaling; Dopaminergic synapse;Glutamatergic synapse;Alzheimer's disease;Cholinergic synapse;Serotonergic synapse;Insulin secretion;Dilated cardiomyopathy;Amphetamine addiction;GABAergic synapse
details
Besides, the expression of miRNA-328 was negatively correlated with TCONS_00075467. We further demonstrated that TCONS_00075467 could sponge miRNA-328 in vitro and in vivo to regulate the downstream protein coding gene CACNA1C. In addition, miRNA-328 could partly reverse the effects of TCONS_00075467 on electrical remodeling.
details
Altered long non-coding RNA expression profile in rabbit atria with atrial fibrillation: TCONS_00075467 modulates atrial electrical remodeling by sponging miR-328 to regulate CACNA1C.
Atrial fibrillation J Mol Cell Cardiol 28546098