| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| NEAT1 | miR-101-3p | EZH2 | EZH2；ENX-1；ENX1；EZH1；EZH2b；KMT6；KMT6A；WVS；WVS2 | details | details
In our research, lncRNA-NEAT1 was specifically upregulated in BC cell lines and promoted BC cell growth through targeting miR-101. Knockdown of NEAT1 inhibited the proliferation and DNA synthesis of human BC cell in vitro. In addition, the regulation of EZH2 by miR-101 was required in NEAT1 induced BC cell growth. These findings indicated that NEAT1 might suppress the tumor growth via miR-101 dependent EZH2 regulation.
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The long non-coding RNA NEAT1 interacted with miR-101 modulates breast cancer growth by targeting EZH2
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Breast Cancer | Arch Biochem Biophys | 28034643 |
| SPRY4-IT1 | miR-101-3p | EZH2 | EZH2；ENX-1；ENX1；EZH1；EZH2b；KMT6；KMT6A；WVS；WVS2 | details | details
Importantly, SPRY4-IT1 could directly interact with miR-101-3p and down-regulation of miR-101-3p efficiently reversed the suppression of EZH2 induced by SPRY4-IT1 shRNA.
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LncRNA SPRY4-IT1 sponges miR-101-3p to promote proliferation and metastasis of bladder cancer cells through up-regulating EZH2
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Bladder Cancer | Cancer Lett | 27998761 |
| SNHG1 | miR-101-3p | SOX9 | SOX9；CMD1；CMPD1；SRA1；SRXX2；SRXY10 | details | details
In addition, we identified that SOX9 acted as a target of miR-101-3p, and SOX9 played the oncogenic role in NSCLC by activating Wnt/β-catenin signaling pathway.
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Upregulated lncRNA SNHG1 contributes to progression of non-small cell lung cancer through inhibition of miR-101-3p and activation of Wnt/β-catenin signaling pathway
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Non-Small Cell Lung Cancer | Oncotarget | 28147312 |
| HOTAIR | miR-101-3p | SRF | SRF；MCM1 | details
MAPK signaling pathway；HTLV-I infection；Viral carcinogenesis
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In addition, miR-101-3p could directly target and suppress the expression of the serum response factor (SRF) gene, which is a transcription factor of HOTAIR, a well-characterized tumor promoter lncRNA. miR-101-3p negatively regulated SRF-mediated transcription of HOTAIR.
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MiR-101-3p Suppresses HOX Transcript Antisense RNA (HOTAIR)-induced Proliferation and Invasion Through Directly Targeting SRF in Gastric Carcinoma Cells
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Gastric Carcinoma | Oncol Res | 28251884 |
| HOTAIR | miR-101-3p | SRF | SRF；MCM1 | details
MAPK signaling pathway；HTLV-I infection；Viral carcinogenesis
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details
In addition, miR-101-3p could directly target and suppress the expression of the serum response factor (SRF) gene, which is a transcription factor of HOTAIR, a well-characterized tumor promoter lncRNA.
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details
MiR-101-3p Suppresses HOX Transcript Antisense RNA (HOTAIR)-induced Proliferation and Invasion Through Directly Targeting SRF in Gastric Carcinoma Cells
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Gastric Carcinoma | Oncol Res | 28251884 |