Jak-STAT signaling pathway；Natural killer cell mediated cytotoxicity；Leukocyte transendothelial migration；Neurotrophin signaling pathway；Adipocytokine signaling pathway；Epithelial cell signaling in Helicobacter pylori infection；Herpes simplex infection；Proteoglycans in cancer；Renal cell carcinoma；Chronic myeloid leukemia

LINC00673 is able to reinforce the interaction of PTPN11 with PRPF19, an E3 ubiquitin ligase, and promote PTPN11 degradation through ubiquitination, which causes diminished SRC-ERK oncogenic signaling and enhanced activation of the STAT1-dependent antitumor response. A G>A change at rs11655237 in exon 4 of LINC00673 creates a target site for miR-1231 binding, which diminishes the effect of LINC00673 in an allele-specific manner and thus confers susceptibility to tumorigenesis.

Pancreatic cancer risk variant in LINC00673 creates a miR-1231 binding site and interferes with PTPN11 degradation