LncCeRBase

Welcome to the LncCeRBase DataBase!
LncRNA MiRNA Gene Gene name Pathway Name Description Title Disease/Tissue Journal PubMed ID
PVT1 miR-186 Twist1 TWIST1;ACS3;BPES2;BPES3;CRS;CRS1;CSO;SCS;TWIST;bHLHa38 details
Proteoglycans in cancer
details
We then confirmed that PVT1 acts as a sponge for miRNA-186-5p and positively regulates Twist1 by a sponge effect. Therefore, this study has revealed a novel MECHANISM for the promotion of EMT in prostate cancer by PVT1. Our findings suggest that the PVT1/miR-186/Twist1 regulatory axis may be a new therapeutic target for prostate cancer.
details
Long noncoding RNA PVT1 promotes EMT via mediating microRNA-186 targeting of Twist1 in prostate cancer
Prostate cancer Gene 29452232
ASLNC02525 miR-489-3p twist1 TWIST1;ACS3;BPES2;BPES3;CRS;CRS1;CSO;SCS;TWIST;bHLHa38 details
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The mechanism study revealed that ASLNC02525, as an RNA sponge, broke the negative regulation of twist1 by hsa-miRNA-489-3p, and once ASLNC02525 was silenced, the highly expressed hsa-miRNA?489-3p regained its regulation on twist1 and inhibited the proliferation and invasion.
details
Inhibition of proliferation and invasion of hepatocellular carcinoma cells by lncRNA-ASLNC02525 silencing and the mechanism.
Hepatocellular carcinoma Int J Oncol 28713968