Transcriptional misregulation in cancer

Mechanisticlly, we demonstrated that H19 functions as a competing endogenous RNA (ceRNA) to sponge miRNA let-7a, leading to an increase in a let-7a target, the key regulator of tumor metastasis HMGA2, which is enriched in TSCC tissues and cell lines. Intriguingly, inhibition of let-7a significantly rescued short hairpin H19 (shH19) induced decrease of TSCC migration and invasion. These findings revealed that H19/let-7a/HMGA2/EMT axis plays a critical role in the regulation of TSCC migration and invasion, which may provide a new therapeutic target for TSCC cancers.

H19 facilitates tongue squamous cell carcinoma migration and invasion via sponging miR-let-7.