Hepatitis B；MAPK signaling pathway；ErbB signaling pathway；Cell cycle；PI3K-Akt signaling pathway；Transcriptional misregulation in cancer；Bladder cancer；Wnt signaling pathway；Colorectal cancer；Endometrial cancer；Acute myeloid leukemia；TGF-beta signaling pathway；Hippo signaling pathway；Small cell lung cancer；Proteoglycans in cancer；Thyroid cancer；Jak-STAT signaling pathway；Pathways in cancer；HTLV-I infection；Chronic myeloid leukemia；Epstein-Barr virus infection

Furthermore, CCAT1 could up-regulated c-Myc via its competing endogenous RNA (ceRNA) activity on miR-155.

Long Non-Coding RNA CCAT1 Acts as a Competing Endogenous RNA to Regulate Cell Growth and Differentiation in Acute Myeloid Leukemia

Ubiquitin mediated proteolysis

Further, MALAT1 suppresses cell viability by down-regulating miR-155. FBXW7 mRNA was identified as a direct target of miR-155 in glioma. The miR-155-induced tumorigenesis is mediated through FBXW7 function. Finally, we found that MALAT1 positively regulated FBXW7 expression, which was responsible for glioma progression mediated by MALAT1-miR-155 pathway.

Tumor-suppressive function of long noncoding RNA MALAT1 in glioma cells by suppressing miR-155 expression and activating FBXW7 function