| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| H19 | miR-138 | HMGA1 | HMGA1；HMG-R；HMGA1A；HMGIY | details | details
Taken together, our research indicated an H19-miR138-HMGA1 pathway in regulating the migration and invasion of colon cancer, providing new insight for treatment of colon cancer.
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details
H19 promotes the migration and invasion of colon cancer by sponging miR-138 to upregulate the expression of HMGA1
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Colon Cancer | Int J Oncol | 28358427 |
| H19 | miR-138 | ZEB1 | ZEB1；AREB6；BZP；DELTAEF1；FECD6；NIL2A；PPCD3；TCF8；ZFHEP；ZFHX1A | details
Transcriptional misregulation in cancer
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details
Furthermore, by using bioinformatics study and RNA immunoprecipitation combined with luciferase reporter assays, we demonstrated that H19 functioned as a competing endogenous RNA (ceRNA) for miR-138 and miR-200a, antagonized their functions and led to the de-repression of their endogenous targets Vimentin, ZEB1, and ZEB2, all of which were core marker genes for mesenchymal cells.
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details
The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer
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Colorectal Cancer | Oncotarget | 26068968 |
| H19 | miR-138 | ZEB2 | ZEB2；HSPC082；SIP-1；SIP1；SMADIP1；ZFHX1B | details | details
Furthermore, by using bioinformatics study and RNA immunoprecipitation combined with luciferase reporter assays, we demonstrated that H19 functioned as a competing endogenous RNA (ceRNA) for miR-138 and miR-200a, antagonized their functions and led to the de-repression of their endogenous targets Vimentin, ZEB1, and ZEB2, all of which were core marker genes for mesenchymal cells.
|
details
The lncRNA H19 promotes epithelial to mesenchymal transition by functioning as miRNA sponges in colorectal cancer
|
Colorectal Cancer | Oncotarget | 26068968 |