Moreover, circ-0016347 was identified as a sponge of miR-214 that upregulated the expression of caspase-1, which is the functional target of miR-214.

Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells.

Bacterial invasion of epithelial cells；Wnt signaling pathway；Hippo signaling pathway；Arrhythmogenic right ventricular cardiomyopathy (ARVC)；Focal adhesion；Colorectal cancer；Adherens junction；Tight junction；Leukocyte transendothelial migration；Melanogenesis；Prostate cancer；Basal cell carcinoma；Pathogenic Escherichia coli infection；HTLV-I infection；Endometrial cancer；Proteoglycans in cancer；Pathways in cancer；Thyroid cancer

Association of DANCR with CTNNB1 blocked the repressing effect of microRNA (miR)-214, miR-320a, and miR-199a on CTNNB1.

Long noncoding RNA DANCR increases stemness features of hepatocellular carcinoma by derepression of CTNNB1

Collectively, these findings identify Plscr4 as a negative regulator of cardiac hypertrophy in vivo and in vitro due to its regulation of the miR-214-Mfn2 axis, suggesting that Plscr4 might act as a therapeutic target for the treatment of cardiac hypertrophy and heart failure.

The lncRNA Plscr4 Controls Cardiac Hypertrophy by Regulating miR-214.