Transcriptional misregulation in cancer

This epigenetic silencing of miR-218 by CCAT1 induces an altered cell cycle transition through BMI1 and provides a new mechanism for CSE-induced lung carcinogenesis.

Epigenetic silencing of miR-218 by the lncRNA CCAT1, acting via BMI1, promotes an altered cell cycle transition in the malignant transformation of HBE cells induced by cigarette smoke extract

Hepatitis B；MAPK signaling pathway；ErbB signaling pathway；Cell cycle；PI3K-Akt signaling pathway；Transcriptional misregulation in cancer；Bladder cancer；Wnt signaling pathway；Colorectal cancer；Endometrial cancer；Acute myeloid leukemia；TGF-beta signaling pathway；Hippo signaling pathway；Small cell lung cancer；Proteoglycans in cancer；Thyroid cancer；Jak-STAT signaling pathway；Pathways in cancer；HTLV-I infection；Chronic myeloid leukemia；Epstein-Barr virus infection

Furthermore, CCAT1 could up-regulated c-Myc via its competing endogenous RNA (ceRNA) activity on miR-155.

Long Non-Coding RNA CCAT1 Acts as a Competing Endogenous RNA to Regulate Cell Growth and Differentiation in Acute Myeloid Leukemia

Taken together, lncRNA CCAT1 regulates the sensitivity of paclitaxel in NPC cells via miR-181a/CPEB2 axis.

LncRNA CCAT1 modulates the sensitivity of paclitaxel in nasopharynx cancers cells via miR-181a/CPEB2 axis

Spliceosome

Post-transcriptional CCAT1 silencing by miR-490 significantly suppressed GC cell migration. Furthermore, miR-490 directly bound to the hnRNPA1 mRNA 3'-UTR to repress its translation.

The long noncoding RNA colon cancer-associated transcript-1/miR-490 axis regulates gastric cancer cell migration by targeting hnRNPA1

In cytoplasm, CCAT1 regulates HOXB13 as a molecular decoy for miR-7, a microRNA that targets both CCAT1 and HOXB13, thus facilitating cell growth and migration.

H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma

Jak-STAT signaling pathway

Mechanistic investigations found that CCAT1 could serve as a scaffold for two distinct epigenetic modification complexes (5? domain of CCAT1 binding Polycomb Repressive Complex 2 (PRC2) while 3? domain of CCAT1 binding SUV39H1) and modulate the histone methylation of promoter of SPRY4 (sprouty RTK signaling antagonist 4) in nucleus

H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma