LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
UCA1 | miR-216b | FGFR1 | FGFR1;BFGFR;CD331;CEK;FGFBR;FGFR-1;FLG;FLT-2;FLT2;HBGFR;HH2;HRTFDS;KAL2;N-SAM;OGD;bFGF-R-1 | details
MAPK signaling pathway;PI3K-Akt signaling pathway;Adherens junction;Regulation of actin cytoskeleton;Pathways in cancer;Proteoglycans in cancer;Prostate cancer;Melanoma
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In addition, UCA1 could reverse the inhibitory effect of miR-216b on the growth and metastasis of HCC cells, which might be involved in the derepression of fibroblast growth factor receptor 1 (FGFR1) expression, a target gene of miR-216b, and the activation of ERK signaling pathway.
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Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway
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Hepatocellular Carcinoma | Oncotarget | 25760077 |