| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| CASC2 | miR-18a | PIAS3 | PIAS3；:ZMIZ5 | details
Ubiquitin mediated proteolysis；Jak-STAT signaling pathway
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details
Further functional experiments indicate that CASC2 could directly upregulate PIAS3 expression by functioning as a competing endogenous RNA (ceRNA) for miR-18a.
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The long noncoding RNA CASC2 functions as a competing endogenous RNA by sponging miR-18a in colorectal cancer
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Colorectal Cancer | Sci Rep | 27198161 |
| CASC2 | miR-181a | PTEN | PTEN；10q23del；BZS；CWS1；DEC；GLM2；MHAM；MMAC1；PTEN1；TEP1 | details
p53 signaling pathway；Inositol phosphate metabolism；Prostate cancer；Phosphatidylinositol signaling system；mTOR signaling pathway；PI3K-Akt signaling pathway；Focal adhesion；Tight junction；Hepatitis B；Pathways in cancer；Melanoma；Endometrial cancer；Glioma；Small cell lung cancer
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CASC2 up-regulated PTEN protein and down-regulated p-AKT protein through regulating miR-181a, and the effect of CASC2 on PTEN and p-AKT could be partially restored by miR-181a. With TMZ-resistant glioma tissues, miR-181a was up-regulated while PTEN was down-regulated.
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LncRNA CASC2 Interacts With miR-181a to Modulate Glioma Growth and Resistance to TMZ Through PTEN Pathway
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Glioma | J Cell Biochem | 28121023 |