mTOR signaling pathway；HIF-1 signaling pathway；Hypertrophic cardiomyopathy (HCM)；Glioma；Prostate cancer；Oocyte meiosis；p53 signaling pathway；PI3K-Akt signaling pathway；Proteoglycans in cancer；Melanoma；Focal adhesion；Long-term depression；Transcriptional misregulation in cancer；Ovarian steroidogenesis；Progesterone-mediated oocyte maturation；Aldosterone-regulated sodium reabsorption；Pathways in cancer；Dilated cardiomyopathy

Furthermore, we identified MHENCR as a competitively endogenous RNA, which specifically bound to miR-425 and miR-489, upregulated their target genes IGF1 and SPIN1 expression, and further activated PI3K-Akt pathway.

Long noncoding RNA MHENCR promotes melanoma progression via regulating miR-425/489-mediated PI3K-Akt pathway