| LncRNA | MiRNA | Gene | Gene name | Pathway Name | Description | Title | Disease/Tissue | Journal | PubMed ID |
| UCA1 | miR-216b | FGFR1 | FGFR1；BFGFR；CD331；CEK；FGFBR；FGFR-1；FLG；FLT-2；FLT2；HBGFR；HH2；HRTFDS；KAL2；N-SAM；OGD；bFGF-R-1 | details
MAPK signaling pathway；PI3K-Akt signaling pathway；Adherens junction；Regulation of actin cytoskeleton；Pathways in cancer；Proteoglycans in cancer；Prostate cancer；Melanoma
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In addition, UCA1 could reverse the inhibitory effect of miR-216b on the growth and metastasis of HCC cells, which might be involved in the derepression of fibroblast growth factor receptor 1 (FGFR1) expression, a target gene of miR-216b, and the activation of ERK signaling pathway.
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Upregulated lncRNA-UCA1 contributes to progression of hepatocellular carcinoma through inhibition of miR-216b and activation of FGFR1/ERK signaling pathway
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Hepatocellular Carcinoma | Oncotarget | 25760077 |
| MALAT1 | miR-216b | HIF-2a | EPAS1；ECYT4；HIF2A；HLF；MOP2；PASD2；bHLHe73 | details
Pathways in cancer；Renal cell carcinoma
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It was HIF-2α, but not HIF-1α induced MALAT1 upregulation in HCC cells. Dual luciferase assay demonstrated that there were at least two binding sites of miR-26b in MALAT1.
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The HIF-2α-MALAT1-miR-216b axis regulates multi-drug resistance of hepatocellular carcinoma cells via modulating autophagy
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Hepatocellular Carcinoma | Biochem Biophys Res Commun | 27524242 |