NF-kappa B signaling pathway；Ubiquitin mediated proteolysis；Apoptosis；Focal adhesion；Toxoplasmosis；HTLV-I infection；Pathways in cancer；Small cell lung cancer

We further confirmed this outcome by comparing the expression of circDOCK1, miR‑196a‑5p and BIRC3 in oral squamous carcinoma tissue with those in para‑carcinoma tissue, and examining the expression profile of circRNAs in oral squamous carcinoma tissue and para‑carcinoma tissue with microarray. Our results demonstrated that circDOCK1 regulated BIRC3 expression by functioning as a competing endogenous RNA (ceRNA) and participated in the process of OSCC apoptosis. Thus, we propose that circDOCK1 could represent a novel potential biomarker and therapeutic target of OSCC.

CircDOCK1 suppresses cell apoptosis via inhibition of miR?196a?5p by targeting BIRC3 in OSCC